Anti-IFNGR1 antibody [MM0339-9U19] (ab90405)

Overview

  • Product nameAnti-IFNGR1 antibody [MM0339-9U19]
    See all IFNGR1 primary antibodies
  • Description
    Mouse monoclonal [MM0339-9U19] to IFNGR1
  • Tested applicationsSuitable for: WB, Neutralising, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human recombinant IFNGR1 extracellular domain

  • General notesReconstituted antibody should be aliquoted and can be stored frozen at < -20 for at least six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Properties

Applications

Our Abpromise guarantee covers the use of ab90405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 54 kDa.
Neutralising Use at an assay dependent concentration.
Flow Cyt 1/50 - 1/200. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • FunctionReceptor for interferon gamma. Two receptors bind one interferon gamma dimer.
  • Involvement in diseaseDefects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
  • Sequence similaritiesBelongs to the type II cytokine receptor family.
    Contains 2 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Post-translational
    modifications
    Phosphorylated at Ser/Thr residues.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Antiviral Protein Type II antibody
    • Antiviral protein, type 2 antibody
    • AVP type II antibody
    • AVP, type 2 antibody
    • CD 119 antibody
    • CD119 antibody
    • CD119 antigen antibody
    • CDw119 antibody
    • FLJ45734 antibody
    • IFN gamma R alpha antibody
    • IFN gamma R antibody
    • IFN gamma R1 antibody
    • IFN-gamma receptor 1 antibody
    • IFN-gamma-R1 antibody
    • IFNG R1 antibody
    • IFNGR 1 antibody
    • IFNGR antibody
    • IFNGR1 antibody
    • Immune interferon receptor 1 antibody
    • Immune interferon receptor for antibody
    • INGR1_HUMAN antibody
    • Interferon gamma receptor 1 antibody
    • Interferon gamma receptor alpha chain antibody
    • Interferon gamma receptor alpha chain precursor antibody
    see all

References for Anti-IFNGR1 antibody [MM0339-9U19] (ab90405)

ab90405 has not yet been referenced specifically in any publications.

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