Anti-IFNGR1 (phospho Y457) antibody (ab61062)


  • Product nameAnti-IFNGR1 (phospho Y457) antibody
    See all IFNGR1 primary antibodies
  • Description
    Rabbit polyclonal to IFNGR1 (phospho Y457)
  • Specificityab61062 detects endogenous levels of IFNGR1 only when phosphorylated at tyrosine 457.
  • Tested applicationsSuitable for: WB, IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic phosphopeptide derived from human IFNGR1 around the phosphorylation site of tyrosine 457 (GYpDKP).

  • Positive control
    • Human brain tissue, COS7 cell extract.



Our Abpromise guarantee covers the use of ab61062 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 80 kDa (predicted molecular weight: 54 kDa).
IHC-P 1/50 - 1/100.
ELISA 1/20000.


  • FunctionReceptor for interferon gamma. Two receptors bind one interferon gamma dimer.
  • Involvement in diseaseDefects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
  • Sequence similaritiesBelongs to the type II cytokine receptor family.
    Contains 2 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Post-translational
    Phosphorylated at Ser/Thr residues.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Antiviral Protein Type II antibody
    • Antiviral protein, type 2 antibody
    • AVP type II antibody
    • AVP, type 2 antibody
    • CD 119 antibody
    • CD119 antibody
    • CD119 antigen antibody
    • CDw119 antibody
    • FLJ45734 antibody
    • IFN gamma R alpha antibody
    • IFN gamma R antibody
    • IFN gamma R1 antibody
    • IFN-gamma receptor 1 antibody
    • IFN-gamma-R1 antibody
    • IFNG R1 antibody
    • IFNGR 1 antibody
    • IFNGR antibody
    • IFNGR1 antibody
    • Immune interferon receptor 1 antibody
    • Immune interferon receptor for antibody
    • INGR1_HUMAN antibody
    • Interferon gamma receptor 1 antibody
    • Interferon gamma receptor alpha chain antibody
    • Interferon gamma receptor alpha chain precursor antibody
    see all

Anti-IFNGR1 (phospho Y457) antibody images

  • Immunohistochemistry analysis of paraffin-embedded human brain tissue using IFNGR1 (phospho Y457) antibody (ab61062) at 1/50 - 1/100 dilution, in the presence (right panel) or absence (left panel) of phosphopeptide.
  • All lanes : Anti-IFNGR1 (phospho Y457) antibody (ab61062) at 1/500 dilution

    Lane 1 : COS7 cell extract with no phosphopeptide
    Lane 2 : COS7 cell extract with phosphopeptide

    Predicted band size : 54 kDa
    Observed band size : 80 kDa (why is the actual band size different from the predicted?)

References for Anti-IFNGR1 (phospho Y457) antibody (ab61062)

ab61062 has not yet been referenced specifically in any publications.

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