Overview

  • Product nameAnti-IGF2 antibody
    See all IGF2 primary antibodies
  • Description
    Goat polyclonal to IGF2
  • SpecificityAnti-Human IGF II will neutralize the biological activity of rhIGF II. It does not neutralize the biological activity of rhIGFI. By ELISA, the antibody shows no cross-reactivity with other cytokines tested.
  • Tested applicationsSuitable for: ELISA, WB, Neutralisingmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein (Human).

Properties

Applications

Our Abpromise guarantee covers the use of ab10730 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use a concentration of 0.5 - 1 µg/ml. 0.5-1 µg/ml antibody detects 3 ng/well of rhIGF-II.
WB Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 20 kDa. 0.1-0.2 µg/ml antibody detects rhIGF-II at 2 ng/lane under non-reducing and reducing conditions.
Neutralising Use a concentration of 0.025 - 0.075 µg/ml.

Target

  • FunctionThe insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
    Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
  • Involvement in diseaseEpigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SIRS) [MIM:180860]. SIRS is a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations.
  • Sequence similaritiesBelongs to the insulin family.
  • Post-translational
    modifications
    O-glycosylated with a core 1 or possibly core 8 glycan.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • C11orf43 antibody
    • IGF 2 antibody
    • IGF II antibody
    • IGF-II antibody
    • IGF2 antibody
    • IGF2_HUMAN antibody
    • IGFII antibody
    • INSIGF antibody
    • insulin like growth factor 2 (somatomedin A) antibody
    • Insulin like Growth Factor 2 antibody
    • Insulin like growth factor II antibody
    • Insulin like growth factor II precursor antibody
    • Insulin like growth factor type 2 antibody
    • pp9974 antibody
    • Preptin antibody
    • putative insulin like growth factor II associated protein antibody
    • Somatomedin A antibody
    • Somatomedin-A antibody
    see all

References for Anti-IGF2 antibody (ab10730)

ab10730 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting Abcam regarding our Anti-IGF21 antibodies. I have confirmed with the laboratory that our other IGF2 antibody, ab10730, has not been tested for cross-reactivity with IGF1. It's ability to neutralise the bioactivity of recombi...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"