Overview

  • Product nameAnti-IGFBP2 antibody [1.A.16]
    See all IGFBP2 primary antibodies
  • Description
    Mouse monoclonal [1.A.16] to IGFBP2
  • SpecificityRecognizes human IGFBP 2 on ELISA analysis.
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Yeast derived recombinant protein (Human).

Properties

Applications

Our Abpromise guarantee covers the use of ab4243 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 35 kDa.

Target

  • FunctionInhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • Sequence similaritiesContains 1 IGFBP N-terminal domain.
    Contains 1 thyroglobulin type-1 domain.
  • DomainThe C-terminus is required for IGF-binding and growth inhibition.
  • Post-translational
    modifications
    O-glycosylated.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • BP 2 antibody
    • BP2 antibody
    • IBP 2 antibody
    • IBP-2 antibody
    • IBP2 antibody
    • IBP2_HUMAN antibody
    • IGF binding protein 2 antibody
    • IGF BP53 antibody
    • IGF-binding protein 2 antibody
    • IGFBP 2 antibody
    • IGFBP-2 antibody
    • IGFBP2 antibody
    • IGFBP53 antibody
    • Insulin like growth factor binding protein 2 36kDa antibody
    • Insulin like growth factor binding protein 2 antibody
    • Insulin like growth factor-binding protein 2 precursor antibody
    • Insulin-like growth factor-binding protein 2 antibody
    see all

References for Anti-IGFBP2 antibody [1.A.16] (ab4243)

This product has been referenced in:
  • Wang C  et al. Human adipocytes stimulate invasion of breast cancer MCF-7 cells by secreting IGFBP-2. PLoS One 10:e0119348 (2015). WB ; Human . Read more (PubMed: 25747684) »
  • Walker G  et al. Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer. Clin Cancer Res 13:1438-44 (2007). Read more (PubMed: 17332286) »

See all 2 Publications for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (glioma cell-line U87MG)
Loading amount 50 µg
Specification glioma cell-line U87MG
Gel Running Conditions Reduced Denaturing
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 23°C
Username

Mr. Paul Eve

Verified customer

Submitted Jan 21 2008

Thank you for your patience. Concerning ab4243, Insulin-Like Growth Factor Binding Protein 2 (IGFBP2), the positive controls are: T98G cell lysate, MES-SA/Dx5 cell lysate, or human placenta. Please let me know if I can be of further assistance.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"