Anti-IGFBP3 antibody - N-terminal (ab75988)

Overview

  • Product nameAnti-IGFBP3 antibody - N-terminal
    See all IGFBP3 primary antibodies
  • Description
    Rabbit polyclonal to IGFBP3 - N-terminal
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse
  • Immunogen

    KLH-conjugated synthetic peptide selected from the N-terminal region of Rat IGFBP3

  • Positive control
    • WB: HepG2 cell line lysate; IHC: Human hepatocarcinoma tissue .

Properties

Applications

Our Abpromise guarantee covers the use of ab75988 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Predicted molecular weight: 32 kDa.
ELISA 1/1000.
IHC-P 1/10 - 1/50.

Target

  • FunctionIGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • Tissue specificityExpressed by most tissues. Present in plasma.
  • Sequence similaritiesContains 1 IGFBP N-terminal domain.
    Contains 1 thyroglobulin type-1 domain.
  • Developmental stageIGFBP3 levels are higher during extrauterine life and peak during puberty.
  • DomainThe thyroglobulin type-1 domain mediates interaction with HN.
  • Post-translational
    modifications
    Phosphorylation sites are present in the extracelllular medium.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Acid stable subunit of the 140 K IGF complex antibody
    • Binding protein 29 antibody
    • Binding protein 53 antibody
    • BP 53 antibody
    • BP53 antibody
    • Growth hormone dependent binding protein antibody
    • IBP 3 antibody
    • IBP-3 antibody
    • IBP3 antibody
    • IBP3_HUMAN antibody
    • IGF binding protein 3 antibody
    • IGF-binding protein 3 antibody
    • IGFBP 3 antibody
    • IGFBP-3 antibody
    • IGFBP3 antibody
    • Insulin Like Growth Factor Binding Protein 3 antibody
    • Insulin-like growth factor binding protein 3 precursor antibody
    • Insulin-like growth factor-binding protein 3 antibody
    see all

Anti-IGFBP3 antibody - N-terminal images

  • Anti-IGFBP3 antibody - N-terminal (ab75988) at 1/60 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 32 kDa
    Observed band size : 32 kDa
    Additional bands at : 46 kDa. We are unsure as to the identity of these extra bands.
  • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue with 1/10-1/50 ab75988, used in conjunction with a peroxidase-conjugated secondary antibody, followed by DAB staining.

References for Anti-IGFBP3 antibody - N-terminal (ab75988)

ab75988 has not yet been referenced specifically in any publications.

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