Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab4257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/100 - 1/1000.
WB 1/100 - 1/1000. Predicted molecular weight: 30 kDa.

Target

  • FunctionIGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • Tissue specificityOsteosarcoma, and at lower levels in liver, kidney and brain.
  • Sequence similaritiesContains 1 IGFBP N-terminal domain.
    Contains 1 thyroglobulin type-1 domain.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • IBP 5 antibody
    • IBP-5 antibody
    • IBP5 antibody
    • IBP5_HUMAN antibody
    • IGF binding protein 5 antibody
    • IGF BP5 antibody
    • IGF-binding protein 5 antibody
    • IGFBP 5 antibody
    • IGFBP-5 antibody
    • IGFBP5 antibody
    • Insulin like growth factor binding protein 5 antibody
    • Insulin-like growth factor-binding protein 5 antibody
    see all

References for Anti-IGFBP5 antibody [1.A.18] (ab4257)

This product has been referenced in:
  • Greenall SA  et al. Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer. J Biol Chem 288:59-68 (2013). Read more (PubMed: 23166326) »
  • Sokolovic A  et al. Insulin-like growth factor binding protein 5 enhances survival of LX2 human hepatic stellate cells. Fibrogenesis Tissue Repair 3:3 (2010). WB ; Human . Read more (PubMed: 20163708) »

See all 3 Publications for this product

Product Wall

Thank you for your enquiry. This antibody was tested in Indirect ELISA using the immunogen human recombinant IGF-binding Protein 5. The immunogen was coated on microtiter plates, blocked and stained with ab4257 at a dilution of 1:50. We do not have...

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Thank you very much for your patience, I have only just heard back from the antibody's originator. The molecular weight is 23 kDa (252 amino acids) according to a reference which describes all 8 ILGFBP isoforms. J. Kostecka, J. Blahovec. Endocrine ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"