Anti-IGFBP6 antibody (ab109765)
Key features and details
- Goat polyclonal to IGFBP6
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-IGFBP6 antibody
See all IGFBP6 primary antibodies -
Description
Goat polyclonal to IGFBP6 -
Host species
Goat -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Sheep, Cow, Pig -
Immunogen
Synthetic peptide:
C-RPQDVNRRDQQRNP
, corresponding to internal sequence amino acids 128-141 of Human IGFBP6 -
Positive control
- Human Skeletal Muscle tissue and Human Adrenal Gland lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab109765 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 25 kDa.
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IHC-P |
Use a concentration of 5 µg/ml.
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Notes |
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WB
Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 25 kDa. |
IHC-P
Use a concentration of 5 µg/ml. |
Target
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Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. -
Sequence similarities
Contains 1 IGFBP N-terminal domain.
Contains 1 thyroglobulin type-1 domain. -
Post-translational
modificationsO-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 404186 Cow
- Entrez Gene: 3489 Human
- Omim: 146735 Human
- SwissProt: Q05718 Cow
- SwissProt: P24592 Human
- Unigene: 274313 Human
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Alternative names
- IBP 6 antibody
- IBP-6 antibody
- IBP6 antibody
see all
Images
Protocols
Datasheets and documents
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Datasheet download
References (4)
ab109765 has been referenced in 4 publications.
- Chen H et al. Alterations of mRNA and lncRNA profiles associated with the extracellular matrix and spermatogenesis in goats. Anim Biosci 35:544-555 (2022). PubMed: 34530511
- Nikulin S et al. Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells. Front Genet 12:662843 (2021). PubMed: 34149804
- Silva LM et al. Integration of Two In-depth Quantitative Proteomics Approaches Determines the Kallikrein-related Peptidase 7 (KLK7) Degradome in Ovarian Cancer Cell Secretome. Mol Cell Proteomics 18:818-836 (2019). PubMed: 30705123
- Zeng C et al. Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis. Oncol Lett 13:4161-4168 (2017). PubMed: 28588703