General notesab94189 is a 293T cell transfected lysate in which Human IGFBP6 has been transiently over-expressed using a pCMV-IGFBP6 plasmid. The lysate is provided in 1X Sample Buffer.
Note: For more details about how the transfected lysate was prepared view the preparation notes.
BackgroundFunction: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Similarity: Contains 1 IGFBP N-terminal domain.
Contains 1 thyroglobulin type-1 domain.
PTM: O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.