Anti-IgG + IgM + IgA antibody (Alkaline Phosphatase) (ab101164)

Overview

  • Product nameAnti-IgG + IgM + IgA antibody (Alkaline Phosphatase)
  • Description
    Goat polyclonal to IgG + IgM + IgA (Alkaline Phosphatase)
  • ConjugationAlkaline Phosphatase
  • SpecificityRecognizes murine IgG (all subclasses), IgA and IgM.
  • Tested applicationsSuitable for: ELISA, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Mouse IgG purified from normal Mouse serum; Mouse IgA and IgM purified from ascitic fluid.

Properties

Applications

Our Abpromise guarantee covers the use of ab101164 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/3000.
IHC-Fr Use at an assay dependent dilution.

Target

  • RelevanceIgG is a monomeric immunoglobulin, built of two heavy chains and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins in humans. This is the only isotype that can pass through the human placenta, thereby providing protection to the fetus in its first weeks of life before its own immune system has developed. It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%). IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B-cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA.
  • Cellular localizationSecreted
  • Alternative names
    • Immunoglobulin A antibody
    • Immunoglobulin A antibody antibody
    • Immunoglobulin G antibody
    • Immunoglobulin G antibody antibody
    • Immunoglobulin M antibody
    • Immunoglobulin M antibody antibody
    see all

References for Anti-IgG + IgM + IgA antibody (Alkaline Phosphatase) (ab101164)

ab101164 has not yet been referenced specifically in any publications.

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