Overview

  • Product nameAnti-IgM antibody [UCH-B1]
    See all IgM primary antibodies
  • Description
    Mouse monoclonal [UCH-B1] to IgM
  • Tested applicationsSuitable for: ICC/IF, IHC-Fr, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human prolymphocytic leukaemia B cells.

  • General notes

    UCH-B1 antigen (85kD) is detected on a sub-population of B lymphocytes, probably related to stage of activation or maturation. UCH-B1 may be useful for differential diagnosis of B cell leukaemias and as a marker of prolymphocytic leukaemia.

    Does not work on formalin fixed and parrafin embedded tissues.

     

     

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • PurityIgG fraction
  • Primary antibody notesUCH-B1 antigen (85kD) is detected on a sub-population of B lymphocytes, probably related to stage of activation or maturation. UCH-B1 may be useful for differential diagnosis of B cell leukaemias and as a marker of prolymphocytic leukaemia.
  • ClonalityMonoclonal
  • Clone numberUCH-B1
  • MyelomaNS0
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab18201 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

Acetone fixed.

Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • RelevanceIgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type. Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated.
  • Cellular localizationIsoform 1: Secreted. During differentiation, B lymphocytes switch from expression of membrane bound IgM to secretion of IgM. Isoform 2: Cell membrane; Single pass type I membrane protein.
  • Database links
  • Alternative names
    • AGM1 antibody
    • Constant region of heavy chain of IgM antibody
    • DKFZp686I15196 antibody
    • DKFZp686I15212 antibody
    • FLJ00385 antibody
    • Hepatitis B virus receptor binding protein antibody
    • Ig mu chain C region antibody
    • IGHM antibody
    • IgM heavy chain constant region antibody
    • Immunoglobulin heavy constant mu antibody
    • Immunoglobulin mu chain antibody
    • Imunoglobulin heavy chain antibody
    • Imunoglobulin heavy chain constant region mu antibody
    • Imunoglobulin heavy chain mu constant region antibody
    • MGC104996 antibody
    • MGC52291 antibody
    • MU antibody
    • VH antibody
    see all

References for Anti-IgM antibody [UCH-B1] (ab18201)

This product has been referenced in:

See all 4 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"