Validated using a knockout cell line

Anti-IKB alpha antibody [E130] (ab32518)

Publishing research using ab32518? Please let us know so that we can cite the reference in this datasheet.

ab32518 has been referenced in 65 publications.

  • Wen H  et al. Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma. Nat Med 24:154-164 (2018). WB . PubMed: 29291352
  • Hernandes MS  et al. Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain. J Neuroinflammation 15:45 (2018). PubMed: 29452577
  • Liu XY  et al. Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. Front Physiol 9:102 (2018). PubMed: 29520236
  • Hashemi P  et al. Compounds producing an effective combinatorial regimen for disruption of HIV-1 latency. EMBO Mol Med 10:160-174 (2018). WB ; Human . PubMed: 29246970
  • Cao W  et al. Homeobox a5 Promotes White Adipose Tissue Browning Through Inhibition of the Tenascin C/Toll-Like Receptor 4/Nuclear Factor Kappa B Inflammatory Signaling in Mice. Front Immunol 9:647 (2018). PubMed: 29651293
  • Kong D  et al. Schizandrin A enhances chemosensitivity of colon carcinoma cells to 5-fluorouracil through up-regulation of miR-195. Biomed Pharmacother 99:176-183 (2018). WB . PubMed: 29331856
  • Han J & Wang W Effects of tanshinol on markers of bone turnover in ovariectomized rats and osteoblast cultures. PLoS One 12:e0181175 (2017). PubMed: 28746340
  • Wang L  et al. Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-?B Pathway. Front Pharmacol 8:266 (2017). PubMed: 28588482
  • Wang B  et al. Fangchinoline inhibits migration and causes apoptosis of human breast cancer MDA-MB-231 cells. Oncol Lett 14:5307-5312 (2017). WB ; Human . PubMed: 29098027
  • Gan L  et al. Reduced Endoplasmic Reticulum Stress-Mediated Autophagy Is Required for Leptin Alleviating Inflammation in Adipose Tissue. Front Immunol 8:1507 (2017). PubMed: 29250056
  • Cheng Z  et al. Lactobacillus raisesin vitroanticancer effect of geniposide in HSC-3 human oral squamous cell carcinoma cells. Exp Ther Med 14:4586-4594 (2017). WB . PubMed: 29104666
  • Luo Q  et al. Sodium fluoride induces renal inflammatory responses by activating NF-?B signaling pathway and reducing anti-inflammatory cytokine expression in mice. Oncotarget 8:80192-80207 (2017). PubMed: 29113295
  • Luo J  et al. Ursolic acid inhibits breast cancer growth by inhibiting proliferation, inducing autophagy and apoptosis, and suppressing inflammatory responses via the PI3K/AKT and NF-?B signaling pathwaysin vitro. Exp Ther Med 14:3623-3631 (2017). PubMed: 29042957
  • Zeng X  et al. Acylated and unacylated ghrelin inhibit atrophy in myotubes co-cultured with colon carcinoma cells. Oncotarget 8:72872-72885 (2017). PubMed: 29069832
  • Liu YJ  et al. Effects and mechanism of dexmedetomidine on neuronal cell injury induced by hypoxia-ischemia. BMC Anesthesiol 17:117 (2017). PubMed: 28854873
  • Ma Y  et al. Sanguinarine protects against osteoarthritis by suppressing the expression of catabolic proteases. Oncotarget 8:62900-62913 (2017). PubMed: 28968958
  • Yang G  et al. Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1ß-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-?B Pathway. Biomed Res Int 2017:8686207 (2017). PubMed: 29333456
  • Deng H  et al. Sodium fluoride induces apoptosis in mouse splenocytes by activating ROS-dependent NF-?B signaling. Oncotarget 8:114428-114441 (2017). PubMed: 29383091
  • Peng T  et al. Centrosomal protein 55 activates NF-?B signalling and promotes pancreatic cancer cells aggressiveness. Sci Rep 7:5925 (2017). PubMed: 28724890
  • Shi C  et al. Cooperative down-regulation of ribosomal protein L10 and NF-?B signaling pathway is responsible for the anti-proliferative effects by DMAPT in pancreatic cancer cells. Oncotarget 8:35009-35018 (2017). PubMed: 28388532
  • Meng Z  et al. A20 Ameliorates Intracerebral Hemorrhage-Induced Inflammatory Injury by Regulating TRAF6 Polyubiquitination. J Immunol 198:820-831 (2017). PubMed: 27986908
  • Vander Lugt B  et al. Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation. J Cell Biol 216:779-792 (2017). WB ; Mouse . PubMed: 28130292
  • Hu J  et al. BMSC paracrine activity attenuates interleukin-1ß-induced inflammation and apoptosis in rat AF cells via inhibiting relative NF-?B signaling and the mitochondrial pathway. Am J Transl Res 9:79-89 (2017). WB ; Rat . PubMed: 28123635
  • Sun MJ  et al. An essential role for the intra-oocyte MAPK activity in the NSN-to-SN transition of germinal vesicle chromatin configuration in porcine oocytes. Sci Rep 6:23555 (2016). WB . PubMed: 27009903
  • Yang GY  et al. Influence of orally fed a select mixture of Bacillus probiotics on intestinal T-cell migration in weaned MUC4 resistant pigs following Escherichia coli challenge. Vet Res 47:71 (2016). WB . PubMed: 27424033
  • Kashyap T  et al. Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-?B deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death. Oncotarget 7:78883-78895 (2016). WB, ICC/IF ; Human . PubMed: 27713151
  • Turner JG  et al. XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of I?Ba and overcomes acquired proteasome inhibitor resistance in human multiple myeloma. Oncotarget 7:78896-78909 (2016). WB, Flow Cyt, ICC/IF ; Human . PubMed: 27806331
  • Xu M  et al. Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Promotes Hepatic Stellate Cells Migration via Canonical NF-?B/MMP9 Pathway. PLoS One 11:e0167658 (2016). WB ; Human . PubMed: 27907201
  • Roy A  et al. BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T Transgenic Mouse Model of Parkinson's Disease. Sci Rep 6:22067 (2016). PubMed: 26916519
  • Tattoli I  et al. NLRX1 Acts as an Epithelial-Intrinsic Tumor Suppressor through the Modulation of TNF-Mediated Proliferation. Cell Rep 14:2576-86 (2016). PubMed: 26971996
  • Zeng Z  et al. Nitrostyrene Derivatives Act as RXRa Ligands to Inhibit TNFa Activation of NF-?B. Cancer Res 75:2049-60 (2015). PubMed: 25795708
  • Tang YL  et al. TLR4/NF-?B signaling contributes to chronic unpredictable mild stress-induced atherosclerosis in ApoE-/- mice. PLoS One 10:e0123685 (2015). WB ; Mouse . PubMed: 25860573
  • Nakayama T  et al. Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination. Am J Hum Genet 96:709-19 (2015). WB ; Human . PubMed: 25865492
  • Gravina GL  et al. KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models. BMC Cancer 15:941 (2015). PubMed: 26620414
  • Hu S  et al. Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen-activated protein kinase kinase signaling pathways. Mol Med Rep 12:6745-51 (2015). Human . PubMed: 26502751
  • Sinha K  et al. Morin protects gastric mucosa from nonsteroidal anti-inflammatory drug, indomethacin induced inflammatory damage and apoptosis by modulating NF-?B pathway. Biochim Biophys Acta 1850:769-783 (2015). PubMed: 25603542
  • Cumming KT  et al. Effects of vitamin C and E supplementation on endogenous antioxidant systems and heat shock proteins in response to endurance training. Physiol Rep 2:N/A (2014). WB ; Human . PubMed: 25293598
  • Skalniak L  et al. MCPIP1 contributes to the toxicity of proteasome inhibitor MG-132 in HeLa cells by the inhibition of NF-?B. Mol Cell Biochem 395:253-63 (2014). WB ; Human . PubMed: 24992982
  • Tobón-Arroyave SI  et al. Immunoexpression of NF-?B and their inhibitory subunits I?Ba and I?Bß in giant cell lesions of the jaws: implications for their clinical behavior. J Oral Pathol Med N/A:N/A (2014). PubMed: 25413222
  • Yan M  et al. IKKa restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation. Nat Commun 5:3661 (2014). PubMed: 24739462
  • Haemmig S  et al. miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas. Cell Death Dis 5:e1279 (2014). WB . PubMed: 24901050
  • Chen R  et al. Transcriptome profiling reveals that the SM22a-regulated molecular pathways contribute to vascular pathology. J Mol Cell Cardiol 72:263-72 (2014). WB ; Mouse . PubMed: 24735829
  • Wann AK  et al. The primary cilium influences interleukin-1ß-induced NF?B signalling by regulating IKK activity. Cell Signal 26:1735-42 (2014). WB ; Mouse . PubMed: 24726893
  • Zhang ZL  et al. Therapeutic effect of a hydroxynaphthoquinone fraction on dextran sulfate sodium-induced ulcerative colitis. World J Gastroenterol 20:15310-8 (2014). Mouse . PubMed: 25386079
  • Dvoriantchikova G & Ivanov D Tumor necrosis factor-alpha mediates activation of NF-?B and JNK signaling cascades in retinal ganglion cells and astrocytes in opposite ways. Eur J Neurosci 40:3171-8 (2014). PubMed: 25160799
  • Le CH  et al. Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure. Circ Heart Fail 7:172-83 (2014). PubMed: 24284026
  • Mediero A  et al. Activation of EPAC1/2 is essential for osteoclast formation by modulating NF?B nuclear translocation and actin cytoskeleton rearrangements. FASEB J 28:4901-13 (2014). PubMed: 25122553
  • Skalniak L  et al. Proteasome inhibitor MG-132 induces MCPIP1 expression. FEBS J 280:2665-74 (2013). WB ; Human . PubMed: 23551903
  • Hussein SZ  et al. Gelam honey attenuates carrageenan-induced rat paw inflammation via NF-?B pathway. PLoS One 8:e72365 (2013). WB ; Rat . PubMed: 24015236
  • Mudaliar MA  et al. Comparative gene expression profiling identifies common molecular signatures of NF-?B activation in canine and human diffuse large B cell lymphoma (DLBCL). PLoS One 8:e72591 (2013). WB . PubMed: 24023754
  • Kim SM  et al. Intermittent Hypoxia Can Aggravate Motor Neuronal Loss and Cognitive Dysfunction in ALS Mice. PLoS One 8:e81808 (2013). WB ; Mouse . PubMed: 24303073
  • Akinsete JA  et al. Consumption of high ?-3 fatty acid diet suppressed prostate tumorigenesis in C3(1) Tag mice. Carcinogenesis 33:140-8 (2012). WB ; Mouse . PubMed: 22045025
  • Almeida MQ  et al. Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations. J Clin Endocrinol Metab 97:E687-93 (2012). PubMed: 22259056
  • Herranz C  et al. Reduced innate immune response, apoptosis, and virus release in cells cured of respiratory syncytial virus persistent infection. Virology 410:56-63 (2011). PubMed: 21093006
  • King AE  et al. An additive interaction between the NFkappaB and estrogen receptor signalling pathways in human endometrial epithelial cells. Hum Reprod 25:510-8 (2010). IHC-P ; Human . PubMed: 19955102
  • Li ZH  et al. Hepatitis C virus core protein induces malignant transformation of biliary epithelial cells by activating nuclear factor-kappaB pathway. J Gastroenterol Hepatol 25:1315-20 (2010). WB, IP ; Human . PubMed: 20594262
  • Stewart ME & Roy P Role of cellular caspases, nuclear factor-kappa B and interferon regulatory factors in Bluetongue virus infection and cell fate. Virol J 7:362 (2010). WB ; Human . PubMed: 21134281
  • Bournazou I  et al. Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin. J Clin Invest 119:20-32 (2009). WB ; Human . PubMed: 19033648
  • Ramadas RA  et al. Surfactant protein A enhances production of secretory leukoprotease inhibitor and protects it from cleavage by matrix metalloproteinases. J Immunol 182:1560-7 (2009). WB ; Human . PubMed: 19155504
  • Zhou Y  et al. Enhanced airway inflammation and remodeling in adenosine deaminase-deficient mice lacking the A2B adenosine receptor. J Immunol 182:8037-46 (2009). WB ; Mouse . PubMed: 19494329
  • Gariboldi S  et al. Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of beta-defensin 2 via TLR2 and TLR4. J Immunol 181:2103-10 (2008). WB ; Human . PubMed: 18641349
  • Bournazos S  et al. Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status. Arterioscler Thromb Vasc Biol 28:1491-8 (2008). WB . PubMed: 18497306
  • Palazzo M  et al. Sodium-dependent glucose transporter-1 as a novel immunological player in the intestinal mucosa. J Immunol 181:3126-36 (2008). WB ; Human . PubMed: 18713983
  • Turnbull CM  et al. A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages. J Inflamm (Lond) 5:12 (2008). WB ; Human . PubMed: 18671842
  • Gu SX  et al. Protein methionine oxidation augments reperfusion injury in acute ischemic stroke. JCI Insight 1:N/A (0). PubMed: 27294204


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