Anti-IKB beta (phospho T19) antibody (ab63510)
Key features and details
- Rabbit polyclonal to IKB beta (phospho T19)
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-IKB beta (phospho T19) antibody
See all IKB beta primary antibodies -
Description
Rabbit polyclonal to IKB beta (phospho T19) -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human IKB beta (phospho T19).
Database link: Q15653 -
General notes
Detects IkB beta only when phosphorylated at threonine 19.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site -
Primary antibody notes
Detects IkB beta only when phosphorylated at threonine 19. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab63510 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 37 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 37 kDa. |
Target
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Function
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. -
Tissue specificity
Expressed in all tissues examined. -
Sequence similarities
Belongs to the NF-kappa-B inhibitor family.
Contains 6 ANK repeats. -
Post-translational
modificationsPhosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. -
Cellular localization
Cytoplasm. Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 4793 Human
- Omim: 604495 Human
- SwissProt: Q15653 Human
- Unigene: 9731 Human
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Alternative names
- I kappa B beta antibody
- I-kappa-B-beta antibody
- IkappaBbeta antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab63510 has not yet been referenced specifically in any publications.