Anti-IKB epsilon (phospho S22) antibody (ab51146)

Overview

  • Product nameAnti-IKB epsilon (phospho S22) antibody
    See all IKB epsilon primary antibodies
  • Description
    Rabbit polyclonal to IKB epsilon (phospho S22)
  • SpecificityDetects endogenous levels of IkB-e only when phosphorylated at serine 22.
  • Tested applicationsSuitable for: IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic phosphopeptide derived from human IkB-e around the phosphorylation site of serine 22 (I-E-SP-L-R).

  • Positive control
    • Human breast carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab51146 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
ELISA 1/40000.

Target

  • FunctionInhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
  • Tissue specificityHighly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
  • Sequence similaritiesBelongs to the NF-kappa-B inhibitor family.
    Contains 6 ANK repeats.
  • Post-translational
    modifications
    Serine phosphorylated; followed by proteasome-dependent degradation.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • I kappa B epsilon antibody
    • I-kappa-B-epsilon antibody
    • IkappaBepsilon antibody
    • IkB E antibody
    • IkB-E antibody
    • IkB-epsilon antibody
    • IKBE antibody
    • IKBE_HUMAN antibody
    • MGC72568 antibody
    • NF kappa B inhibitor epsilon antibody
    • NF kappa BIE antibody
    • NF-kappa-B inhibitor epsilon antibody
    • NF-kappa-BIE antibody
    • NFkappa BIE antibody
    • NFkappaB inhibitor epsilon antibody
    • NFKBIE antibody
    • Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor epsilon antibody
    • OTTHUMP00000016522 antibody
    • Slc35b2 antibody
    • solute carrier family 35, member B2 antibody
    see all

Anti-IKB epsilon (phospho S22) antibody images

  • ab51146 at 1/50 dilution staining Human breast carcinoma tissue with and without blocking peptide; paraffin embedded.

References for Anti-IKB epsilon (phospho S22) antibody (ab51146)

ab51146 has not yet been referenced specifically in any publications.

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