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Rabbit polyclonal to IKB epsilon (phospho S22)
ab75907 detects endogenous levels of IKB epsilon only when phosphorylated at serine 22.
Synthetic phosphopeptide derived from human IKB epsilon around the phosphorylation site of serine 22 (I-E-S
Human breast carcinoma tissue; 293 cell extracts treated with TNF-alpha (20ng/ml, 15min).
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg 2+ and Ca 2+), 150mM Sodium chloride, pH 7.4
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Immunogen affinity purified
ab75907 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Predicted molecular weight: 38 kDa.
1/50 - 1/100.
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
Belongs to the NF-kappa-B inhibitor family.
Contains 6 ANK repeats.
Serine phosphorylated; followed by proteasome-dependent degradation.
Information by UniProt
I kappa B epsilon antibody
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"