Anti-IKB zeta antibody (ab155142)
Key features and details
- Rabbit polyclonal to IKB zeta
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-IKB zeta antibody
See all IKB zeta primary antibodies -
Description
Rabbit polyclonal to IKB zeta -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Rat, Cow -
Immunogen
Recombinant fragment, corresponding to a region within amino acids 303-609 of Human IKB zeta (UniProt Q9BYH8).
-
Positive control
- HeLa nuclear lysate.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab155142 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/500 - 1/3000. Predicted molecular weight: 78 kDa.
|
Notes |
---|
WB
1/500 - 1/3000. Predicted molecular weight: 78 kDa. |
Target
-
Function
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis. -
Tissue specificity
Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. -
Sequence similarities
Contains 7 ANK repeats. -
Cellular localization
Nucleus. Aggregated in dot-like structures. Colocalizes with NCOR2. - Information by UniProt
-
Database links
- Entrez Gene: 282713 Cow
- Entrez Gene: 64332 Human
- Entrez Gene: 304005 Rat
- Omim: 608004 Human
- SwissProt: Q9BE45 Cow
- SwissProt: Q9BYH8 Human
- Unigene: 319171 Human
-
Alternative names
- FLJ30225 antibody
- FLJ34463 antibody
- I-kappa-B-zeta antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (2)
ab155142 has been referenced in 2 publications.
- Liu S et al. IL-17A synergistically enhances TLR3-mediated IL-36? production by keratinocytes: A potential role in injury-amplified psoriatic inflammation. Exp Dermatol 28:233-239 (2019). PubMed: 30614571
- Zhou K et al. Potential role of TET2 in gastric cancer cisplatin resistance. Pathol Res Pract 215:152637 (2019). PubMed: 31570278