Overview

  • Product name
  • Description
    Rabbit polyclonal to IKB zeta
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 303-609 of Human IKB zeta (UniProt Q9BYH8).

  • Positive control
    • HeLa nuclear lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab155142 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 78 kDa.

Target

  • Function
    Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis.
  • Tissue specificity
    Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.
  • Sequence similarities
    Contains 7 ANK repeats.
  • Cellular localization
    Nucleus. Aggregated in dot-like structures. Colocalizes with NCOR2.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ30225 antibody
    • FLJ34463 antibody
    • I-kappa-B-zeta antibody
    • Ikappa B zeta antibody
    • IkappaB zeta antibody
    • IkappaBzeta antibody
    • IkB-zeta antibody
    • IKBZ antibody
    • IKBZ_HUMAN antibody
    • IKBzeta antibody
    • IL-1 inducible nuclear ankyrin-repeat protein antibody
    • INAP antibody
    • MAIL antibody
    • MAIL protein antibody
    • Molecule possessing ankyrin repeats induced by lipopolysaccharide antibody
    • NF-kappa-B inhibitor zeta antibody
    • NFKBIZ antibody
    • Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor zeta antibody
    see all

Images

  • Anti-IKB zeta antibody (ab155142) at 1/1000 dilution + HeLa nuclear lysate at 20 µg

    Predicted band size: 78 kDa



    7.5% SDS PAGE

References

ab155142 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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