Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab7894 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

General Info

  • Alternative names
    • chuk
    • CHUK1
    • Conserved Helix Loop Helix Ubiquitous Kinase
    • Conserved helix loop ubiquitous kinase
    • Conserved helix-loop-helix ubiquitous kinase
    • I Kappa B Kinase 1
    • I Kappa B Kinase Alpha
    • I-kappa-B kinase 1
    • I-kappa-B kinase alpha
    • IkappaB kinase
    • IkB kinase alpha subunit
    • IkBKA
    • IKK 1
    • IKK A
    • IKK a kinase
    • IKK-A
    • IKK-alpha
    • IKK1
    • IKKA
    • IKKA_HUMAN
    • Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells
    • Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit
    • Inhibitor of nuclear factor kappa-B kinase subunit alpha
    • NFKBIKA
    • Nuclear Factor Kappa B Inhibitor Kinase Alpha
    • Nuclear factor NF kappa B inhibitor kinase alpha
    • Nuclear factor NF-kappa-B inhibitor kinase alpha
    • Nuclear factor NFkappaB inhibitor kinase alpha
    • Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor
    • TCF-16
    • TCF16
    • Transcription factor 16
    see all
  • Function
    Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
  • Tissue specificity
    Widely expressed.
  • Involvement in disease
    Defects in CHUK are the cause of cocoon syndrome (COCOS) [MIM:613630]; also known as fetal encasement syndrome. COCOS is a lethal syndrome characterized by multiple fetal malformations including defective face and seemingly absent limbs, which are bound to the trunk and encased under the skin.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.
    Acetylation of Thr-179 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signaling pathway.
  • Cellular localization
    Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus.
  • Information by UniProt

References

ab7894 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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