Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab56867 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionTranscription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
    • Tissue specificityExpressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
    • Sequence similaritiesBelongs to the Ikaros C2H2-type zinc-finger protein family.
      Contains 6 C2H2-type zinc fingers.
    • Post-translational
      modifications
      Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
    • Cellular localizationNucleus. Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • AIO antibody
      • Aiolos antibody
      • IKAROS family zinc finger 3 (Aiolos) antibody
      • IKAROS family zinc finger 3 antibody
      • Ikaros family zinc finger protein 3 antibody
      • IKZF 3 antibody
      • IKZF3 antibody
      • IKZF3_HUMAN antibody
      • zinc finger DNA binding protein Aiolos antibody
      • Zinc finger protein Aiolos antibody
      • Zinc finger protein subfamily 1A 3 (Aiolos) antibody
      • Zinc finger protein subfamily 1A 3 antibody
      • Zinc finger protein subfamily 1A, member 3 antibody
      • ZNFN1A3 antibody
      see all

    Anti-IKZF3 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56867 IKZF3 antibody at 1ug/ml. Predicted band size of immunogen is 82 kDa

    References for Anti-IKZF3 antibody (ab56867)

    ab56867 has not yet been referenced specifically in any publications.

    Product Wall

    I now have the information from the source of the Anti-IKZF3 antibody (ab56867). Unfortunately, epitope mapping has as yet not been performed with this antibody. We cannot therefore predict which isoforms (apart from isoform 1 which the antibody was ra...

    Read More

    Thank you for contacting us and your interest in our products.

    In regards to the Anti-IKZF3 antibody (ab56867), the antibody is raised against the full lenght recombinantly expressed human protein. From performing sequence alignment, which is...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"