Overview

  • Product nameAnti-IL1 beta antibody [1400.24.17]See all IL1 beta primary antibodies ...
  • Description
    Rat monoclonal [1400.24.17] to IL1 beta
  • SpecificityThis antibody recognizes both the recombinant and the natural form of mouse IL1b.
  • Tested applicationsELISA, Neutralisingmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Mouse IL1 beta

Properties

Applications

Our Abpromise guarantee covers the use of ab13784 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution. Ab13784 can be used as the capture reagent in a two-site sandwich ELISA for measuring mouse IL1b levels using recombinant mouse IL-1b as the standard. This ELISA measured IL1b in mice with a detection range between 10 pg/ml and 3 ng/ml after zymosan induced inflammation. See Oluyomi AO et al.
Neutralising Use at an assay dependent dilution. See Geiger T et al.

Target

  • FunctionProduced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
  • Sequence similaritiesBelongs to the IL-1 family.
  • DomainThe similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
  • Cellular localizationSecreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
  • Information by UniProt
  • Database links
  • Alternative names
    • Catabolin antibody
    • H1 antibody
    • Hematopoietin 1 antibody
    • IFN beta inducing factor antibody
    • IL 1 antibody
    • IL 1 beta antibody
    • IL 1B antibody
    • IL-1 beta antibody
    • IL1 BETA antibody
    • IL1B antibody
    • IL1B_HUMAN antibody
    • IL1F2 antibody
    • Interleukin 1 beta antibody
    • Interleukin 1 beta precursor antibody
    • Interleukin-1 beta antibody
    • LAF antibody
    • OAF antibody
    • Osteoclast activating factor antibody
    • OTTHUMP00000162031 antibody
    • Preinterleukin 1 beta antibody
    • Preinterleukin beta antibody
    • Pro interleukin 1 beta antibody
    see all

References for Anti-IL1 beta antibody [1400.24.17] (ab13784)

This product has been referenced in:
  • Oluyomi AO  et al. Differential effects of prednisolone and indomethacin on zymosan-induced inflammation in a modified murine tissue-chamber model. Inflamm Res 44:350-6 (1995). Read more (PubMed: 8581523) »
  • Geiger T  et al. Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response. Clin Exp Rheumatol 11:515-22 (1993). Read more (PubMed: 8275587) »

See all 2 Publications for this product

Product Wall

Thank you for your inquiry aboutab13784.

I have talked to the lab and they have informed me that the antibody recognizes both the precursor and active form of IL1 Beta.

If there is anything else I can help you with, please let me know.

Thank you for your patience. We produce some of our antibodies in-house and others are sourced from suppliers whose products we believe will be of interest to our customers. This product falls into the latter category. We have just been informed...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"