Overview

  • Product nameAnti-IL1 beta antibody [8516.311]
    See all IL1 beta primary antibodies
  • Description
    Mouse monoclonal [8516.311] to IL1 beta
  • SpecificityBy ELISA and immunoblotting, the antibody shows < 5% cross-reactivity with rhIL1 alpha, rmIL1 beta. In addition the antibody shows no cross-reactivity with rmIl1 alpha, rhIL1 ralpha, rmIL1 ralpha, and rrIL1 ralpha. The antibody will not neutralize the biological activity of rhIL1 alpha, rmIL1 alpha or rmIL1 beta.
  • Tested applicationsELISA, WB, Neutralisingmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant human IL1 beta (rhIL1 beta), expressed in E. coli.

Properties

Applications

Our Abpromise guarantee covers the use of ab10749 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.
Neutralising Use at an assay dependent dilution.

Target

  • FunctionProduced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
  • Sequence similaritiesBelongs to the IL-1 family.
  • DomainThe similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
  • Cellular localizationSecreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
  • Information by UniProt
  • Database links
  • Alternative names
    • Catabolin antibody
    • H1 antibody
    • Hematopoietin 1 antibody
    • IFN beta inducing factor antibody
    • IL 1 antibody
    • IL 1 beta antibody
    • IL 1B antibody
    • IL-1 beta antibody
    • IL1 BETA antibody
    • IL1B antibody
    • IL1B_HUMAN antibody
    • IL1F2 antibody
    • Interleukin 1 beta antibody
    • Interleukin 1 beta precursor antibody
    • Interleukin-1 beta antibody
    • LAF antibody
    • OAF antibody
    • Osteoclast activating factor antibody
    • OTTHUMP00000162031 antibody
    • Preinterleukin 1 beta antibody
    • Preinterleukin beta antibody
    • Pro interleukin 1 beta antibody
    see all

References for Anti-IL1 beta antibody [8516.311] (ab10749)

This product has been referenced in:
  • Lucchesi W  et al. Differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2. J Virol 82:7456-66 (2008). WB, ELISA ; Human . Read more (PubMed: 18480445) »
  • Pioli PA  et al. Lipopolysaccharide-induced IL-1 beta production by human uterine macrophages up-regulates uterine epithelial cell expression of human beta-defensin 2. J Immunol 176:6647-55 (2006). ELISA ; Human . Read more (PubMed: 16709823) »

See all 2 Publications for this product

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"