Specificityab115497 reacts with cell surface and soluble human IL1 Receptor I. The specific epitope is unknown. ab115497 does not block binding of IL-1 to the receptor, and does not cross-react with receptors for human IL-2 or IL-4.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 10 - 100 µg/ml.
Use at an assay dependent concentration.
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Use at an assay dependent concentration. Concentrations of 20-30 ng/ml will bind radiolabeled IL1 Receptor I in a radioimmunoassay format.
FunctionReceptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.
Sequence similaritiesBelongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain.
Interleukin 1 receptor antagonist protein (IRAP) antibody
Interleukin 1 receptor type I antibody
Interleukin receptor 1 antibody
Interleukin-1 receptor alpha antibody
Interleukin-1 receptor type 1 antibody
Interleukin-1 receptor type I antibody
Anti-IL1 Receptor I antibody  images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL1 Receptor I antibody (ab115497)
ab115497, at 10 µg/ml, staining IL1 Receptor I in formalin-fixed, paraffin-embedded Human Placenta tissue by Immunohistochemistry using a biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
References for Anti-IL1 Receptor I antibody  (ab115497)
has not yet been referenced specifically in any publications.
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