• Product nameAnti-IL1 Receptor I antibody
    See all IL1 Receptor I primary antibodies
  • Description
    Rabbit polyclonal to IL1 Receptor I
  • Tested applicationsSuitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to amino acids 18-241 of Human IL1 Receptor I (BC067506).

  • Positive control
    • Human fetal spleen lysate. HeLa cell lysate. Human fetal skin tissue.



Our Abpromise guarantee covers the use of ab106278 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration. PubMed: 24950657
WB 1/500 - 1/1000. Detects a band of approximately 75 kDa (predicted molecular weight: 65 kDa).
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionReceptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.
  • Sequence similaritiesBelongs to the interleukin-1 receptor family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 TIR domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Antigen CD121a antibody
    • CD121 antigen-like family member A antibody
    • CD121a antibody
    • CD121a antigen antibody
    • D2S1473 antibody
    • IL 1 antibody
    • IL 1R 1 antibody
    • IL 1R alpha antibody
    • IL 1RT1 antibody
    • IL-1R-1 antibody
    • IL-1R-alpha antibody
    • IL-1RT-1 antibody
    • IL-1RT1 antibody
    • IL1 inhibitor antibody
    • IL1R antibody
    • IL1R1 antibody
    • IL1R1_HUMAN antibody
    • IL1RA antibody
    • IL1RN antibody
    • IL1RT1 antibody
    • Interleukin 1 receptor alpha type 1 antibody
    • Interleukin 1 receptor antagonist protein (IRAP) antibody
    • Interleukin 1 receptor type I antibody
    • Interleukin receptor 1 antibody
    • Interleukin-1 receptor alpha antibody
    • Interleukin-1 receptor type 1 antibody
    • Interleukin-1 receptor type I antibody
    • p80 antibody
    see all

Anti-IL1 Receptor I antibody images

  • All lanes : Anti-IL1 Receptor I antibody (ab106278) at 1/500 dilution

    Lane 1 : Human fetal spleen lysate
    Lane 2 : HeLa cell lysate

    Predicted band size : 65 kDa
  • ab106278 staining interleukin 1 receptor 1 antibody in foetal epithelial skin tissue by immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Antibody dilution 1/100.

References for Anti-IL1 Receptor I antibody (ab106278)

This product has been referenced in:
  • Oh YS  et al. Effects of bilateral vasectomy on the interleukin 1 system in mouse epididymis. Am J Reprod Immunol N/A:N/A (2016). IHC ; Mouse . Read more (PubMed: 27476761) »
  • Ma L  et al. Interleukin-1 beta guides the migration of cortical neurons. J Neuroinflammation 11:114 (2014). WB, IHC-FoFr, ICC/IF ; Rat . Read more (PubMed: 24950657) »

See all 2 Publications for this product

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ab106278 : sodium citrate buffer (10 mM Sodium citrate, pH 6.0), boil for 15 minutes.

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Frozen sections)
Sample Mouse Tissue sections (Colon, Dorsal Root Ganglia)
Specification Colon, Dorsal Root Ganglia
Fixative Paraformaldehyde
Permeabilization Yes - 0.2% Triton X-100
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C

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Submitted Oct 19 2011