Anti-IL1 Receptor I/IL-1R-1 antibody - C-terminal (ab190078)
Key features and details
- Rabbit polyclonal to IL1 Receptor I/IL-1R-1 - C-terminal
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-IL1 Receptor I/IL-1R-1 antibody - C-terminal
See all IL1 Receptor I/IL-1R-1 primary antibodies -
Description
Rabbit polyclonal to IL1 Receptor I/IL-1R-1 - C-terminal -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human IL1 Receptor I/IL-1R-1 (C terminal) conjugated to keyhole limpet haemocyanin. (From the E487 region) NP_000868.1.
Database link: P14778 -
Positive control
- Human lung, macrophages and prostate carcinoma tissue; HL60 cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab190078 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000. Predicted molecular weight: 65 kDa.
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IHC-P |
Use a concentration of 5 µg/ml.
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Notes |
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WB
1/1000. Predicted molecular weight: 65 kDa. |
IHC-P
Use a concentration of 5 µg/ml. |
Target
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Function
Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2. -
Sequence similarities
Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3554 Human
- Omim: 147810 Human
- SwissProt: P14778 Human
- Unigene: 701982 Human
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Alternative names
- Antigen CD121a antibody
- CD121 antigen-like family member A antibody
- CD121a antibody
see all
Images
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Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung, macrophages labeling IL-1 Receptor I /IL-1R-1 with ab190078 at 5 µg/ml.
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Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostate carcinoma tissue labeling IL-1 Receptor I / IL-1R-1 with ab190078 at 5 µg/ml, followed by peroxidase-conjugated secondary antibody and DAB staining.
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Anti-IL1 Receptor I/IL-1R-1 antibody - C-terminal (ab190078) at 1/60 dilution + HL60 cell lysate at 35 µg
Predicted band size: 65 kDa
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab190078 has been referenced in 1 publication.
- Bergqvist F et al. Divergent roles of prostacyclin and PGE2 in human tendinopathy. Arthritis Res Ther 21:74 (2019). PubMed: 30867043