Overview

  • Product name
    Anti-IL1 Receptor I antibody [REG21]
    See all IL1 Receptor I primary antibodies
  • Description
    Rat monoclonal [REG21] to IL1 Receptor I
  • Specificity
    Binds to soluble mouse interleukin-1 receptor type I. Interleukin-1 signal is transduced through the type I receptor.
  • Tested applications
    Suitable for: IP, Inhibition Assay, WB, Purificationmore details
  • Species reactivity
    Reacts with: Mouse

Properties

Applications

Our Abpromise guarantee covers the use of ab8154 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP
Inhibition Assay
WB
Purification
  • Application notes
    IP: Use at an assay dependent dilution.
    Inhib: Use at an assay dependent dilution.
    P: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution.
    ab8154 can be used for inhibition in biological assays (in vitro and in vivo).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.
    • Sequence similarities
      Belongs to the interleukin-1 receptor family.
      Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 TIR domain.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Antigen CD121a antibody
      • CD121 antigen-like family member A antibody
      • CD121a antibody
      • CD121a antigen antibody
      • D2S1473 antibody
      • IL 1 antibody
      • IL 1R 1 antibody
      • IL 1R alpha antibody
      • IL 1RT1 antibody
      • IL-1R-1 antibody
      • IL-1R-alpha antibody
      • IL-1RT-1 antibody
      • IL-1RT1 antibody
      • IL1 inhibitor antibody
      • IL1R antibody
      • IL1R1 antibody
      • IL1R1_HUMAN antibody
      • IL1RA antibody
      • IL1RN antibody
      • IL1RT1 antibody
      • Interleukin 1 receptor alpha type 1 antibody
      • Interleukin 1 receptor antagonist protein (IRAP) antibody
      • Interleukin 1 receptor type I antibody
      • Interleukin receptor 1 antibody
      • Interleukin-1 receptor alpha antibody
      • Interleukin-1 receptor type 1 antibody
      • Interleukin-1 receptor type I antibody
      • p80 antibody
      see all

    References for Anti-IL1 Receptor I antibody [REG21] (ab8154)

    This product has been referenced in:
    • Pasi S  et al. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response. J Biol Chem 291:12358-69 (2016). Read more (PubMed: 27022030) »

    See 1 Publication for this product

    Product Wall

    No, it is not available in lyophilized form. The highest concentration at which we could supply this product is approximately 1 mg/ml

    This antibody has not yet been tested in immunohistochemistry

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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