Anti-IL10RB antibody [3F9] (ab33401)

Overview

  • Product nameAnti-IL10RB antibody [3F9]
    See all IL10RB primary antibodies
  • Description
    Rat monoclonal [3F9] to IL10RB
  • Tested applicationsSuitable for: Flow Cyt, Functional Studiesmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human) -soluble CD210.

  • General notes


    This antibody has been reported to function as a blocking agent.

Properties

Applications

Our Abpromise guarantee covers the use of ab33401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/100 - 1/200.

Use 10µl of this dilution for 106 cells in 100µl. Due to low expression of CD210, sensitive staining techniques may be required.





ab18450-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
Functional Studies Use at an assay dependent concentration.

Target

  • FunctionShared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IL29.
  • Involvement in diseaseDefects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) [MIM:612567]. It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
  • Sequence similaritiesBelongs to the type II cytokine receptor family.
    Contains 2 fibronectin type-III domains.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cd210 antibody
    • CDw210b antibody
    • CRF2 4 antibody
    • CRF2-4 antibody
    • CRFB4 antibody
    • Cytokine receptor class II antibody
    • Cytokine receptor class II CRF2 4 antibody
    • Cytokine receptor class-II member 4 antibody
    • Cytokine receptor family 2 member 4 antibody
    • Cytokine receptor family II member 4 antibody
    • D21S58 antibody
    • D21S66 antibody
    • I10R2_HUMAN antibody
    • IL-10 receptor subunit beta antibody
    • IL-10R subunit 2 antibody
    • IL-10R subunit beta antibody
    • IL-10R2 antibody
    • IL-10RB antibody
    • IL10R2 antibody
    • IL10RB antibody
    • Interleukin 10 receptor beta antibody
    • Interleukin-10 receptor subunit 2 antibody
    • Interleukin-10 receptor subunit beta antibody
    see all

References for Anti-IL10RB antibody [3F9] (ab33401)

ab33401 has not yet been referenced specifically in any publications.

Product Wall



The concentrations noted on our online datasheets for these products are the only concentrations available at this time. However, one easy way to increase the concentration for these products would be to use a 10KdA moleuclar weight cut off s...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"