Overview

  • Product nameAnti-IL10RB antibody
    See all IL10RB primary antibodies
  • Description
    Rabbit polyclonal to IL10RB
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to amino acids 21-218 of Human IL10RB (BC001903).

  • Positive control
    • Human fetal heart, liver, kidney and muscle lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab106282 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa).
IHC-P Use at an assay dependent concentration.

Target

  • FunctionShared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IL29.
  • Involvement in diseaseDefects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) [MIM:612567]. It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
  • Sequence similaritiesBelongs to the type II cytokine receptor family.
    Contains 2 fibronectin type-III domains.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cd210 antibody
    • CDw210b antibody
    • CRF2 4 antibody
    • CRF2-4 antibody
    • CRFB4 antibody
    • Cytokine receptor class II antibody
    • Cytokine receptor class II CRF2 4 antibody
    • Cytokine receptor class-II member 4 antibody
    • Cytokine receptor family 2 member 4 antibody
    • Cytokine receptor family II member 4 antibody
    • D21S58 antibody
    • D21S66 antibody
    • I10R2_HUMAN antibody
    • IL-10 receptor subunit beta antibody
    • IL-10R subunit 2 antibody
    • IL-10R subunit beta antibody
    • IL-10R2 antibody
    • IL-10RB antibody
    • IL10R2 antibody
    • IL10RB antibody
    • Interleukin 10 receptor beta antibody
    • Interleukin-10 receptor subunit 2 antibody
    • Interleukin-10 receptor subunit beta antibody
    see all

Anti-IL10RB antibody images

  • All lanes : Anti-IL10RB antibody (ab106282) at 1/1000 dilution

    Lane 1 : Human fetal heart lysate
    Lane 2 : Human fetal liver lysate
    Lane 3 : Human fetal muscle lysate
    Lane 4 : Human fetal kidney lysate


    Predicted band size : 37 kDa

References for Anti-IL10RB antibody (ab106282)

ab106282 has not yet been referenced specifically in any publications.

Product Wall

Thank you for that extra information.

I look forward to hearing how you get on with the modifications I suggested. I would also add that performing a "no primary" control would probably be worthwhile doing as this would indicate if any of th...

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Thank you for contacting us and reporting the problems experienced when using anti-IL10RB antibody (ab106282).
I am sorry to hear that this antibody is not providing satisfactory results. The details provided will enable us to investigate this cas...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"