Anti-IL-10RB/IL-10R2 antibody (ab106282)
Key features and details
- Rabbit polyclonal to IL-10RB/IL-10R2
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-IL-10RB/IL-10R2 antibody
See all IL-10RB/IL-10R2 primary antibodies -
Description
Rabbit polyclonal to IL-10RB/IL-10R2 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant fragment. This information is proprietary to Abcam and/or its suppliers.
-
Positive control
- Human fetal heart, liver, kidney and muscle lysates
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Lyophilized:Reconstitute with 200ul distilled H2O. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituent: 1% BSA -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab106282 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use at an assay dependent concentration.
|
|
WB |
1/1000 - 1/2000. Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa).
|
Notes |
---|
IHC-P
Use at an assay dependent concentration. |
WB
1/1000 - 1/2000. Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa). |
Target
-
Function
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IL29. -
Involvement in disease
Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) [MIM:612567]. It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. -
Sequence similarities
Belongs to the type II cytokine receptor family.
Contains 2 fibronectin type-III domains. -
Cellular localization
Membrane. - Information by UniProt
-
Database links
- Entrez Gene: 3588 Human
- Entrez Gene: 16155 Mouse
- Entrez Gene: 304091 Rat
- Omim: 123889 Human
- SwissProt: Q08334 Human
- SwissProt: Q61190 Mouse
- Unigene: 654593 Human
- Unigene: 4154 Mouse
-
Alternative names
- Cd210 antibody
- CDw210b antibody
- CRF2 4 antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (1)
ab106282 has been referenced in 1 publication.
- Reemann P et al. Expression of class II cytokine genes in children's skin. Acta Derm Venereol 94:386-92 (2014). PubMed: 24284923