Overview

  • Product name
    Anti-IL12 p40 + IL12 p70 antibody [B-P40]
    See all IL12 p40 + IL12 p70 primary antibodies
  • Description
    Mouse monoclonal [B-P40] to IL12 p40 + IL12 p70
  • Specificity
    Recognises both natural and recombinant Human IL12 p40 + p70.
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant Human IL12.

  • General notes


    No effect on IL12-induced proliferation on PHA and IL2 activated lymphocytes.

Properties

Applications

Our Abpromise guarantee covers the use of ab27379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

Suitable for intra cytoplasmic flow cytometry.





ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • Relevance
    IL12 is a heterodimeric cytokine comprised of p35 and p40 subunits. IL12 plays a central role in mediating cell mediated immunity, promoting differentiation of CD4+ T cells to the Th1 subset and of CD8+ T cells into mature cytotoxic T lymphocytes (CTLs). IL12 is a potent stimulator of NK cells. IL12 therapy has been suggested as a method of enhancing cytocidal anti tumour immune responses.
  • Cellular localization
    Secreted
  • Database links
  • Alternative names
    • CLMF p35 antibody
    • CLMF p40 antibody
    • CLMF1 antibody
    • CLMF2 antibody
    • IL12 subunit p35 antibody
    • IL12 subunit p40 antibody
    • IL12A antibody
    • IL12B antibody
    • NKSF antibody
    • NKSF2 antibody
    see all

References

This product has been referenced in:
  • Verreck FA  et al. Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. Proc Natl Acad Sci U S A 101:4560-5 (2004). Read more (PubMed: 15070757) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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