Anti-IL12RB1 antibody [MM0363-7V24] (ab89890)

Overview

  • Product nameAnti-IL12RB1 antibody [MM0363-7V24]
    See all IL12RB1 primary antibodies
  • Description
    Mouse monoclonal [MM0363-7V24] to IL12RB1
  • Specificityab89890 detects IL12RB1.
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to the extracellular domain of Human IL12RB1.

Properties

  • FormLyophilised:Reconstitute the antibody with 200 µl sterile PBS.
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesThe IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • ClonalityMonoclonal
  • Clone numberMM0363-7V24
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab89890 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/50 - 1/200. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • FunctionFunctions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
  • Involvement in diseaseDefects in IL12RB1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
  • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 5 fibronectin type-III domains.
  • DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD212 antibody
    • cluster of differentiation 212 antibody
    • I12R1_HUMAN antibody
    • IL-12 receptor beta component antibody
    • IL-12 receptor subunit beta-1 antibody
    • IL-12R subunit beta-1 antibody
    • IL-12R-beta-1 antibody
    • IL-12RB1 antibody
    • IL12 receptor beta component antibody
    • IL12RB antibody
    • Il12rb1 antibody
    • IMD3 antibody
    • IMD30 antibody
    • Interleukin 12 receptor beta 1 chain antibody
    • Interleukin 12 receptor subunit beta 1 antibody
    • Interleukin-12 receptor subunit beta-1 antibody
    • MGC34454 antibody
    see all

References for Anti-IL12RB1 antibody [MM0363-7V24] (ab89890)

ab89890 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab89890.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"