Overview

  • Product name
  • Description
    Rabbit polyclonal to IL12RB2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 759-788 of Human IL12RB2 (NP_001550.1).

  • Positive control
    • MDA-MB435 cell line lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab107204 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab107204 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 97 kDa.

Target

  • Function
    Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
  • Tissue specificity
    Isoform 2 is expressed at similar levels in both naive and activated T-cells.
  • Sequence similarities
    Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 5 fibronectin type-III domains.
  • Developmental stage
    Maximum levels in Th1 cells between day 3 and day 8 of activation.
  • Domain
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Post-translational
    modifications
    On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • I12R2_HUMAN antibody
    • IL-12 receptor subunit beta-2 antibody
    • IL-12R subunit beta-2 antibody
    • IL-12R-beta-2 antibody
    • IL-12RB2 antibody
    • IL12 receptor beta 2 antibody
    • IL12R beta2 antibody
    • IL12RB2 antibody
    • Interleukin 12 receptor beta 2 antibody
    • Interleukin 12 receptor beta 2 chain antibody
    • Interleukin-12 receptor subunit beta-2 antibody
    • RP11 102M16.1 antibody
    see all

Images

  • Anti-IL12RB2 antibody (ab107204) at 1/100 dilution + MDA-MB435 cell line lysate at 35 µg

    Predicted band size : 97 kDa

References

This product has been referenced in:
  • Quiniou C  et al. Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response. Am J Physiol Regul Integr Comp Physiol 307:R1216-30 (2014). Read more (PubMed: 25354400) »

See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab107204.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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