FunctionReceptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Tissue specificityIsoform 2 is expressed at similar levels in both naive and activated T-cells.
Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily. Contains 5 fibronectin type-III domains.
Developmental stageMaximum levels in Th1 cells between day 3 and day 8 of activation.
DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Post-translational modificationsOn IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.