• Product nameAnti-IL15RA antibody [RM0103-6C38]
    See all IL15RA primary antibodies
  • Description
    Rat monoclonal [RM0103-6C38] to IL15RA
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Recombinant fragment, corresponding to the extracellular domain of Mouse IL15RA



Our Abpromise guarantee covers the use of ab86486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: 1/500 - 1/1000. Predicted molecular weight: 28 kDa (isoform 1).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionReceptor for interleukin-15. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK.
    • Tissue specificityIsoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
    • Sequence similaritiesContains 1 Sushi (CCP/SCR) domain.
    • Post-translational
      A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
      Phosphorylated by activated SYK.
      N-glycosylated and O-glycosylated.
    • Cellular localizationSecreted > extracellular space; Membrane. Nucleus membrane. Mainly found associated with the nuclear membrane and Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle membrane. Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • AA690181 antibody
      • CD215 antibody
      • I15RA_HUMAN antibody
      • IL 15R alpha antibody
      • IL-15 receptor subunit alpha antibody
      • IL-15R-alpha antibody
      • IL-15RA antibody
      • Il15ra antibody
      • Interleukin 15 receptor alpha antibody
      • Interleukin 15 receptor subunit alpha antibody
      • MGC104179 antibody
      • sIL-15 receptor subunit alpha antibody
      • sIL-15R-alpha antibody
      • sIL-15RA antibody
      • Soluble interleukin 15 receptor subunit alpha antibody
      • Soluble interleukin-15 receptor subunit alpha antibody
      see all

    References for Anti-IL15RA antibody [RM0103-6C38] (ab86486)

    This product has been referenced in:
    • Takashima A  et al. Uterine natural killer cells severely decrease in number at gestation day 6 in mice. Biol Reprod 89:101 (2013). WB ; Mouse . Read more (PubMed: 24025738) »
    • Chenoweth MJ  et al. IL-15 can signal via IL-15Ra, JNK, and NF-?B to drive RANTES production by myeloid cells. J Immunol 188:4149-57 (2012). Blocking ; Mouse . Read more (PubMed: 22447977) »

    See all 2 Publications for this product

    Product Wall

    Thank you for your phone call. Unfortunately, I was unable to obtain any more specific information about the immunogen other than that it is the extracellular domain (33-205aa) of mouse IL-15R alpha (Q60819). I hope this helps, please let me know if yo...

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