Overview

  • Product nameAnti-IL16 antibody [59]
    See all IL16 primary antibodies
  • Description
    Mouse monoclonal [59] to IL16
  • SpecificityMAb 59 exhibits no detectable cross-reacting with human albumin serum, Bovine albumin serum and other human cytokines or growth factors tested such as IL-1-beta, IL-8, IL-7 MCAF, TGF-beta-1, EGF, bFGF, GM-CSF, M-CSF, TNF-alpha.
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Purified recombinant human IL-16.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: None
    Constituents: 0.01M PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • Clone number59
  • MyelomaSp2/0-Ag14
  • IsotypeIgG2b
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab18673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB Use a concentration of 2.5 µg/ml. Predicted molecular weight: 67 kDa.

Target

  • FunctionInterleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
    Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
    Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
  • Tissue specificityIsoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation.
  • Sequence similaritiesContains 4 PDZ (DHR) domains.
  • Post-translational
    modifications
    Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
  • Cellular localizationCytoplasm; Cytoplasm. Nucleus and Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • HGNC:5980 antibody
    • HsT19289 antibody
    • IL-16 antibody
    • IL16 antibody
    • IL16_HUMAN antibody
    • Interleukin 16 precursor antibody
    • Interleukin-16 antibody
    • LCF antibody
    • Lymphocyte chemoattractant factor antibody
    • Neuronal interleukin 16 antibody
    • NIL16 antibody
    • prIL 16 antibody
    • PrIL16 antibody
    • Prointerleukin 16 antibody
    see all

References for Anti-IL16 antibody [59] (ab18673)

ab18673 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"