Anti-IL17A Receptor antibody [MM0371-8D15] (ab92608)

Overview

  • Product name
    Anti-IL17A Receptor antibody [MM0371-8D15]
    See all IL17A Receptor primary antibodies
  • Description
    Mouse monoclonal [MM0371-8D15] to IL17A Receptor
  • Tested applications
    Suitable for: WB, Neutralisingmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to the extracellular domain of Human IL17A Receptor.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    Purified from tissue culture supernatant and 0.2 µm filtered.
  • Clonality
    Monoclonal
  • Clone number
    MM0371-8D15
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab92608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
Neutralising
  • Application notes
    Neut: Use at an assay dependent dilution.
    WB: 1/500 - 1/1000. Predicted molecular weight: 96 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.
    • Tissue specificity
      Widely expressed.
    • Involvement in disease
      Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
    • Sequence similarities
      Contains 1 SEFIR domain.
    • Post-translational
      modifications
      Glycosylated.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CANDF5 antibody
      • CD217 antibody
      • CD217 antigen antibody
      • CDw217 antibody
      • CTLA8 antibody
      • HIL 17R antibody
      • hIL17R antibody
      • I17RA_HUMAN antibody
      • IL 17 receptor A antibody
      • IL 17 receptor antibody
      • IL 17RA antibody
      • IL-17 receptor A antibody
      • IL-17RA antibody
      • IL17 antibody
      • IL17A receptor antibody
      • IL17R antibody
      • IL17RA antibody
      • IMD51 antibody
      • Interleukin 17 receptor A antibody
      • Interleukin-17 receptor A antibody
      • MGC10262 antibody
      see all

    References

    This product has been referenced in:
    • Cai K  et al. IL-17A promotes the proliferation of human nasopharyngeal carcinoma cells through p300-mediated Akt1 acetylation. Oncol Lett 13:4238-4244 (2017). Read more (PubMed: 28588706) »

    See 1 Publication for this product

    Customer reviews and Q&As

    Thank you for your inquiry.

    The principle of the neutralization ability of ab92608 is the following:

    IL-17 can stimulate IL-6 secretion from human stromal cells in a dose dependent manner.



    ab92608 can attenuate ...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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