Anti-IL17A Receptor antibody [MM0371-8D15] (ab92608)

Overview

  • Product nameAnti-IL17A Receptor antibody [MM0371-8D15]
    See all IL17A Receptor primary antibodies
  • Description
    Mouse monoclonal [MM0371-8D15] to IL17A Receptor
  • Tested applicationsSuitable for: WB, Neutralisingmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to the extracellular domain of Human IL17A Receptor.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesPurified from tissue culture supernatant and 0.2 µm filtered.
  • ClonalityMonoclonal
  • Clone numberMM0371-8D15
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab92608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
Neutralising
  • Application notesNeut: Use at an assay dependent dilution.
    WB: 1/500 - 1/1000. Predicted molecular weight: 96 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionReceptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.
    • Tissue specificityWidely expressed.
    • Involvement in diseaseDefects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
    • Sequence similaritiesContains 1 SEFIR domain.
    • Post-translational
      modifications
      Glycosylated.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CANDF5 antibody
      • CD217 antibody
      • CD217 antigen antibody
      • CDw217 antibody
      • CTLA8 antibody
      • HIL 17R antibody
      • I17RA_HUMAN antibody
      • IL 17 receptor A antibody
      • IL 17 receptor antibody
      • IL 17RA antibody
      • IL-17 receptor A antibody
      • IL-17RA antibody
      • IL17 antibody
      • IL17A receptor antibody
      • IL17R antibody
      • IL17RA antibody
      • Interleukin 17 receptor A antibody
      • Interleukin-17 receptor A antibody
      • MGC10262 antibody
      see all

    References for Anti-IL17A Receptor antibody [MM0371-8D15] (ab92608)

    ab92608 has not yet been referenced specifically in any publications.

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    The principle of the neutralization ability of ab92608 is the following:

    IL-17 can stimulate IL-6 secretion from human stromal cells in a dose dependent manner.



    ab92608 can attenuate ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"