Anti-IL-17RA Receptor antibody [RM0104-10B27] (ab86487)
Key features and details
- Rat monoclonal [RM0104-10B27] to IL-17RA Receptor
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG2
Overview
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Product name
Anti-IL-17RA Receptor antibody [RM0104-10B27]
See all IL-17RA Receptor primary antibodies -
Description
Rat monoclonal [RM0104-10B27] to IL-17RA Receptor -
Host species
Rat -
Specificity
This antibody detects mouse IL17A Receptor in Western blotting, but not IL17B Receptor.
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Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Recombinant fragment corresponding to Mouse IL-17RA Receptor (extracellular).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Protein A purified -
Purification notes
The IgG fraction of culture supernatant was purified by Protein A affinity chromatography. -
Clonality
Monoclonal -
Clone number
RM0104-10B27 -
Isotype
IgG2 -
Research areas
Associated products
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Compatible Secondaries
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab86487 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use at an assay dependent concentration.
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Notes |
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WB
Use at an assay dependent concentration. |
Target
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Function
Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. -
Tissue specificity
Widely expressed. -
Involvement in disease
Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. -
Sequence similarities
Contains 1 SEFIR domain. -
Post-translational
modificationsGlycosylated. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 16172 Mouse
- SwissProt: Q60943 Mouse
- Unigene: 4481 Mouse
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Alternative names
- CANDF5 antibody
- CD217 antibody
- CD217 antigen antibody
see all
Datasheets and documents
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Datasheet download
References (1)
ab86487 has been referenced in 1 publication.
- Deguise MO et al. Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy. Sci Rep 6:28846 (2016). WB . PubMed: 27349908