Overview

  • Product nameAnti-IL1RAPL1 antibody
    See all IL1RAPL1 primary antibodies
  • Description
    Mouse monoclonal to IL1RAPL1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment: FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKTW RPSIVFKRDT LLIREVREDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES , corresponding to amino acids 151-251 of Human IL1RAPL1

Properties

Applications

Our Abpromise guarantee covers the use of ab56961 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK.
    • Tissue specificityDetected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal liver.
    • Involvement in diseaseDefects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21) [MIM:300143]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
    • Sequence similaritiesBelongs to the interleukin-1 receptor family.
      Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 TIR domain.
    • Cellular localizationCell membrane. Cytoplasm. May localize to the cell body and growth cones of dendrite-like processes.
    • Information by UniProt
    • Database links
    • Alternative names
      • IL 1 RAPL 1 antibody
      • IL 1RAPL 1 antibody
      • IL-1-RAPL-1 antibody
      • IL-1RAPL-1 antibody
      • IL1R8 antibody
      • IL1RAPL 1 antibody
      • IL1RAPL antibody
      • IL1RAPL-1 antibody
      • IL1RAPL1 antibody
      • Interleukin 1 receptor 8 antibody
      • Interleukin 1 receptor accessory protein like 1 antibody
      • Interleukin-1 receptor accessory protein-like 1 antibody
      • IRPL1_HUMAN antibody
      • Mental retardation X linked 10 antibody
      • Mental retardation X linked 21 antibody
      • Mental retardation X linked 34 antibody
      • MRX 21 antibody
      • MRX 34 antibody
      • MRX10 antibody
      • MRX21 antibody
      • MRX34 antibody
      • Oligophrenin 4 antibody
      • Oligophrenin-4 antibody
      • Oligophrenin4 antibody
      • OPHN 4 antibody
      • OPHN4 antibody
      • Three immunoglobulin domain containing IL 1 receptor related 2 antibody
      • Three immunoglobulin domain-containing IL-1 receptor-related 2 antibody
      • TIGIRR 2 antibody
      • TIGIRR-2 antibody
      • TIGIRR2 antibody
      • X linked interleukin 1 receptor accessory protein like 1 antibody
      • X-linked interleukin-1 receptor accessory protein-like 1 antibody
      see all

    Anti-IL1RAPL1 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56961 IL1RAPL1 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-IL1RAPL1 antibody (ab56961)

    This product has been referenced in:
    • Handley MT  et al. Structural and functional deficits in a neuronal calcium sensor-1 mutant identified in a case of autistic spectrum disorder. PLoS One 5:e10534 (2010). WB ; Mouse . Read more (PubMed: 20479890) »

    See 1 Publication for this product

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    There are currently no Abreviews or Questions for ab56961.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"