The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesBL: 1/50.
This will block 50-70% of CTLL proliferative response to 5% Con A sup as a source for mouse IL2. This antibody will also block 50-70% of MLR or T cell proliferation to KLH.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionProduced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Involvement in diseaseNote=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.