Anti-IL2 Receptor alpha antibody [3C7] (Allophycocyanin) (ab25485)

Overview

  • Product nameAnti-IL2 Receptor alpha antibody [3C7] (Allophycocyanin)
    See all IL2 Receptor alpha primary antibodies
  • Description
    Rat monoclonal [3C7] to IL2 Receptor alpha (Allophycocyanin)
  • ConjugationAllophycocyanin. Ex: 645nm, Em: 660nm
  • Specificityab25485 recognises low affinity alpha chain IL2 receptor (MW 55 kDa) (IL2R alpha).
  • Tested applicationsSuitable for: Flow Cyt, IP, Blocking, Inhibition Assaymore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    The details of the immunogen for this antibody are not available.

Properties

Applications

Our Abpromise guarantee covers the use of ab25485 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
IP
Blocking
Inhibition Assay
  • Application notesBL: Use at an assay dependent dilution.
    ab25485 is useful for in vitro blocking of IL2 binding.
    Flow Cyt: Use 0.3µg for 106 cells.
    IP: Use at an assay dependent dilution.
    Inhib: Use at an assay dependent dilution.
    ab25485 inhibits IL2 or mitogen induced T cell proliferation.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionReceptor for interleukin-2.
    • Involvement in diseaseGenetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
    • Sequence similaritiesContains 2 Sushi (CCP/SCR) domains.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Interleukin 2 receptor alpha chain antibody
      • CD25 antibody
      • CD25 antigen antibody
      • IDDM10 antibody
      • IL 2 receptor alpha subunit antibody
      • IL-2 receptor subunit alpha antibody
      • IL-2-RA antibody
      • IL-2R subunit alpha antibody
      • IL2 RA antibody
      • IL2-RA antibody
      • IL2R antibody
      • IL2R, alpha chain antibody
      • IL2RA antibody
      • IL2RA_HUMAN antibody
      • Interleukin 2 receptor alpha antibody
      • Interleukin 2 receptor antibody
      • Interleukin-2 receptor subunit alpha antibody
      • p55 antibody
      • t-cell growth factor receptor antibody
      • TAC antibody
      • TAC antigen antibody
      • TCGFR antibody
      see all

    References for Anti-IL2 Receptor alpha antibody [3C7] (Allophycocyanin) (ab25485)

    This product has been referenced in:
    • Bursen A  et al. The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4. Blood 115:3570-9 (2010). Flow Cyt ; Mouse . Read more (PubMed: 20194896) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"