The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
BL: Use at an assay dependent dilution.
ab25485 is useful for in vitro blocking of IL2 binding.
Flow Cyt: Use 0.3µg for 106 cells.
IP: Use at an assay dependent dilution.
Inhib: Use at an assay dependent dilution.
ab25485 inhibits IL2 or mitogen induced T cell proliferation.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Receptor for interleukin-2.
Involvement in disease
Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.