Anti-IL2 Receptor alpha antibody [7D4] (Biotin) (ab25185)

Overview

  • Product name
    Anti-IL2 Receptor alpha antibody [7D4] (Biotin)
    See all IL2 Receptor alpha primary antibodies
  • Description
    Rat monoclonal [7D4] to IL2 Receptor alpha (Biotin)
  • Conjugation
    Biotin
  • Specificity
    ab25185 reacts with low affinity alpha chain IL-2 receptor (IL-2R alpha), Mr 55 kDa
  • Tested applications
    Suitable for: Flow Cyt, IPmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Tissue/ cell preparation of IL-2-dependent BALB/c mouse helper T-cell clone HT-2 (Mouse)

  • Epitope
    ab25185 reacts with an epitope between amino acids 125 and 212 of IL-2 receptor.

Properties

Applications

Our Abpromise guarantee covers the use of ab25185 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 1µg for 106 cells. ab35773-Rat monoclonal IgM, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.

Target

  • Function
    Receptor for interleukin-2.
  • Involvement in disease
    Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
  • Sequence similarities
    Contains 2 Sushi (CCP/SCR) domains.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Interleukin 2 receptor alpha chain antibody
    • CD25 antibody
    • CD25 antigen antibody
    • IDDM10 antibody
    • IL 2 receptor alpha subunit antibody
    • IL-2 receptor subunit alpha antibody
    • IL-2-RA antibody
    • IL-2R subunit alpha antibody
    • IL2 RA antibody
    • IL2-RA antibody
    • IL2R antibody
    • IL2R, alpha chain antibody
    • IL2RA antibody
    • IL2RA_HUMAN antibody
    • IMD41 antibody
    • Interleukin 2 receptor alpha antibody
    • Interleukin 2 receptor antibody
    • Interleukin-2 receptor subunit alpha antibody
    • p55 antibody
    • t-cell growth factor receptor antibody
    • TAC antibody
    • TAC antigen antibody
    • TCGFR antibody
    see all

References

ab25185 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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