The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FunctionThis is a receptor for interleukin-21.
Tissue specificitySelectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
Sequence similaritiesBelongs to the type I cytokine receptor family. Type 4 subfamily. Contains 2 fibronectin type-III domains.
DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Post-translational modificationsC-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.