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CPDLVCYTDYLQT, corresponding to amino acids 20-32 of Human IL-21 Receptor.
A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21. The receptor for IL-21(IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling. Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Our Abpromise guarantee covers the use of ab2067 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 60 kDa.Can be blocked with IL21 Receptor peptide (ab6226).|
ab2067 has not yet been referenced specifically in any publications.