Anti-IL23 antibody [G23-8] - Low endotoxin, Azide free (ab193252)

Overview

  • Product name
    Anti-IL23 antibody [G23-8] - Low endotoxin, Azide free
    See all IL23 primary antibodies
  • Description
    Rat monoclonal [G23-8] to IL23 - Low endotoxin, Azide free
  • Tested applications
    Suitable for: Neutralising, WB, Functional Studies, Sandwich ELISAmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Recombinant full length protein corresponding to Mouse IL23. (Insect cell-expressed, heterodimer).
    Database link: Q9EQ14

  • General notes

    Endotoxin Level: Less than 0.001 ng/ug antibody, as determined by the LAL assay.

Properties

Applications

Our Abpromise guarantee covers the use of ab193252 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Neutralising Use a concentration of 1.25 µg/ml.

ab193252 has been found to neutralize by 50% the biological effect of 0.1 ng/mL mouse IL23 in an assay of IL17 secretion by mouse splenocytes. The G23-8 antibody has no effect on the bioactivity of mouse IL12 p70.

WB Use at an assay dependent concentration. Predicted molecular weight: 22 kDa.
Functional Studies Use at an assay dependent concentration.
Sandwich ELISA Use a concentration of 1 - 4 µg/ml.

Use as the capture antibody in an IL23 ELISA assay (in conjunction with biotinylated C17.8 antibody).

Target

  • Function
    Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
  • Tissue specificity
    Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
  • Sequence similarities
    Belongs to the IL-6 superfamily.
  • Developmental stage
    Expressed by newborns dendritic cells.
  • Cellular localization
    Secreted. Secreted upon association with IL12B.
  • Information by UniProt
  • Database links
  • Alternative names
    • IL 23 A antibody
    • IL 23 antibody
    • IL 23 subunit alpha antibody
    • IL 23A antibody
    • IL 23p19 antibody
    • IL-23 subunit alpha antibody
    • IL-23-A antibody
    • IL-23p19 antibody
    • IL12B antibody
    • IL23 antibody
    • Il23a antibody
    • IL23A_HUMAN antibody
    • IL23P19 antibody
    • interleukin 12B antibody
    • Interleukin 23 alpha subunit p19 antibody
    • Interleukin 23 p19 subunit antibody
    • interleukin 23 subunit alpha antibody
    • interleukin 23 subunit p19 antibody
    • interleukin six, G CSF related factor antibody
    • Interleukin-23 subunit alpha antibody
    • Interleukin-23 subunit p19 antibody
    • JKA3 induced upon T cell activation antibody
    • MGC79388 antibody
    • P19 antibody
    • SGRF antibody
    see all

References

ab193252 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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