• Product nameAnti-IL23 antibody [HLT2736]
    See all IL23 primary antibodies
  • Description
    Mouse monoclonal [HLT2736] to IL23
  • SpecificityHuman recombinant p40 and p19 with elastin linker.
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human IL23.

  • Positive control
    • Human Adrenal and Lung vasculature tissues; Recombinant Human IL23.


Associated products


Our Abpromise guarantee covers the use of ab110630 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 21 kDa.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionAssociates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
  • Tissue specificitySecreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
  • Sequence similaritiesBelongs to the IL-6 superfamily.
  • Developmental stageExpressed by newborns dendritic cells.
  • Cellular localizationSecreted. Secreted upon association with IL12B.
  • Information by UniProt
  • Database links
  • Alternative names
    • IL 23 A antibody
    • IL 23 antibody
    • IL 23 subunit alpha antibody
    • IL 23A antibody
    • IL 23p19 antibody
    • IL-23 subunit alpha antibody
    • IL-23-A antibody
    • IL-23p19 antibody
    • IL12B antibody
    • IL23 antibody
    • Il23a antibody
    • IL23A_HUMAN antibody
    • IL23P19 antibody
    • interleukin 12B antibody
    • Interleukin 23 alpha subunit p19 antibody
    • Interleukin 23 p19 subunit antibody
    • interleukin 23 subunit alpha antibody
    • interleukin 23 subunit p19 antibody
    • interleukin six, G CSF related factor antibody
    • Interleukin-23 subunit alpha antibody
    • Interleukin-23 subunit p19 antibody
    • JKA3 induced upon T cell activation antibody
    • MGC79388 antibody
    • P19 antibody
    • SGRF antibody
    see all

Anti-IL23 antibody [HLT2736] images

  • Immunohistological staining of Human Adrenal tissue, Formalin-Fixed, Paraffin-Embedded using ab110630 at 10µg/ml dilution.
  • Immunohistological staining of Human Lung vasculature tissue, Formalin-Fixed, Paraffin-Embedded using ab110630 at 10µg/ml dilution.
  • Anti-IL23 antibody [HLT2736] (ab110630) + Recombinant Human IL23 P19

    Predicted band size : 21 kDa

References for Anti-IL23 antibody [HLT2736] (ab110630)

This product has been referenced in:
  • Helbling M  et al. Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patients. Oncotarget 5:4671-82 (2014). IHC . Read more (PubMed: 25015728) »

See 1 Publication for this product

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