Overview

  • Product nameAnti-IL23 Receptor antibody
    See all IL23 Receptor primary antibodies
  • Description
    Rabbit polyclonal to IL23 Receptor
  • SpecificityBased on immunogen sequence, this antibody will recognize the 629 AA, 390 AA and 227 AA forms of human IL-23R.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide:

    IPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTD YKKENTGPLETRDYPQNSLFD

    , corresponding to amino acids 400-470 of Human IL23 Receptor.

  • Positive control
    • Jurkat and NIH3T3 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab22059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 72 kDa (predicted molecular weight: 72 kDa).

Target

  • FunctionAssociates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
  • Tissue specificityExpressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
  • Involvement in diseaseGenetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17) [MIM:612261]. IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
    Genetic variations in IL23R are a cause of susceptibility to psoriasis type 7 (PSORS7) [MIM:605606]. Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
  • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 2 fibronectin type-III domains.
  • Post-translational
    modifications
    Phosphorylated in response to IL23.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • IL 23R antibody
    • IL-23 receptor antibody
    • IL-23R antibody
    • Il23r antibody
    • IL23R_HUMAN antibody
    • Interleukin 23 receptor antibody
    • Interleukin-23 receptor antibody
    see all

Anti-IL23 Receptor antibody images

  • All lanes : Anti-IL23 Receptor antibody (ab22059) at 1 µg/ml

    Lane 1 : Human colon tissue lysate - total protein (ab30051)
    Lane 2 : Mouse colon tissue lysate - total protein (ab29544)
    Lane 3 : Human spleen tissue lysate - total protein (ab29699)
    Lane 4 : Mouse spleen tissue lysate - total protein (ab29293)
    Lane 5 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 6 : Hela Whole Cell Lysate - Staurosporine Treated (24hr, 500nM)
    Lane 7 : NIH 3T3 whole cell lysate (ab7179)
    Lane 8 : Liver (Mouse) Tissue Lysate

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 72 kDa


    Exposure time : 8 minutes

References for Anti-IL23 Receptor antibody (ab22059)

This product has been referenced in:
  • Zwiers A  et al. Cutting Edge: A Variant of the IL-23R Gene Associated with Inflammatory Bowel Disease Induces Loss of MicroRNA Regulation and Enhanced Protein Production. J Immunol 188:1573-7 (2012). WB ; Human . Read more (PubMed: 22262659) »

See 1 Publication for this product

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