SpecificityThis antibody recognizes the N-terminus of mouse CRF-2-12 (IL-28 receptor alpha) protein. This antibody is likely to recognize rat CRF-2-12 (IL-28 receptor alpha) protein due to sequence similiarity. The peptide sequence is < 50 % identical to other sequences in GenBank.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. ab37373-Goat polyclonal IgG, is suitable for use as an isotype control with this antibody.
RelevanceIL28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB.
There are 4 isoforms as result of alternative splicing. It is widely expressed. IL28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain.
Cellular localizationMembrane; Single-pass type I membrane protein