Anti-IL-31RA antibody (ab113498)
Key features and details
- Rabbit polyclonal to IL-31RA
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-IL-31RA antibody -
Description
Rabbit polyclonal to IL-31RA -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant fragment corresponding to Human IL-31RA aa 91-378.
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Positive control
- Jurkat whole cell lysate (ab7899), Human fetal liver, fetal kidney, fetal spleen and fetal colon lysates; Human fetal prostate tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituent: 1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab113498 is purified by a protein affinity column. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab113498 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 83 kDa.
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IHC-P |
1/100 - 1/500.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 83 kDa. |
IHC-P
1/100 - 1/500. |
Target
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Function
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. -
Tissue specificity
Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14-and CD56-positive blood cells and by macrophages (at protein level). -
Sequence similarities
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 5 fibronectin type-III domains. -
Post-translational
modificationsN-glycosylated. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 133396 Human
- Entrez Gene: 218624 Mouse
- Entrez Gene: 688622 Rat
- Omim: 609510 Human
- SwissProt: Q8NI17 Human
- SwissProt: Q8K5B1 Mouse
- Unigene: 55378 Human
- Unigene: 380801 Mouse
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Alternative names
- Class I cytokine receptor antibody
- CRL 3 antibody
- CRL antibody
see all
Images
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All lanes : Anti-IL-31RA antibody (ab113498) at 1/500 dilution
Lane 1 : Jurkat cell lysate
Lane 2 : Human fetal liver lysate
Lane 3 : Human fetal kidney lysate
Lane 4 : Human fetal spleen lysate
Lane 5 : Human fetal colon lysate
Predicted band size: 83 kDa -
ab113498, at 1/100, staining IL31RA in Formalin-fixed, Paraffin-embedded Human fetal prostate tissue by Immunohistochemistry.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab113498 has been referenced in 4 publications.
- Ogura M et al. Prenylated quinolinecarboxylic acid compound-18 prevents sensory nerve fiber outgrowth through inhibition of the interleukin-31 pathway. PLoS One 16:e0246630 (2021). PubMed: 33539470
- Hashimoto T et al. Dermal Periostin: A New Player in Itch of Prurigo Nodularis. Acta Derm Venereol 101:adv00375 (2021). PubMed: 33236123
- Hashimoto T et al. Pathophysiological mechanisms of itch in bullous pemphigoid. J Am Acad Dermatol N/A:N/A (2019). PubMed: 31351883
- Patra V et al. CD11b+ cells markedly express the itch cytokine interleukin-31 in polymorphic light eruption. Br J Dermatol 181:1079-1081 (2019). PubMed: 31049931