Anti-IL36RN antibody [MM0384-2J30] (ab90931)

Overview

  • Product name
    Anti-IL36RN antibody [MM0384-2J30]
    See all IL36RN primary antibodies
  • Description
    Mouse monoclonal [MM0384-2J30] to IL36RN
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length Human IL1F5 protein.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • Clonality
    Monoclonal
  • Clone number
    MM0384-2J30
  • Isotype
    IgG2
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab90931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 17 kDa.

Target

  • Function
    Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
  • Tissue specificity
    Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
  • Involvement in disease
    Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP) [MIM:614204]. PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein.
  • Sequence similarities
    Belongs to the IL-1 family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • AI413231 antibody
    • Family of interleukin 1 delta antibody
    • FIL1 antibody
    • FIL1 delta antibody
    • FIL1(DELTA) antibody
    • FIL1D antibody
    • Fil1delta antibody
    • I36RA_HUMAN antibody
    • IL 1 delta antibody
    • IL 1 related protein 3 antibody
    • IL 1F5 (IL 1HY1, FIL1 delta, IL 1RP3, IL 1L1, IL 1 delta) antibody
    • Il 1h3 antibody
    • IL 1HY1 antibody
    • IL 1L1 antibody
    • IL 1ra homolog antibody
    • IL 1ra homolog; IL1F5 (Canonical product IL 1F5a) antibody
    • IL 1RP3 antibody
    • IL-1 delta antibody
    • IL-1-related protein 3 antibody
    • IL-1F5 antibody
    • IL-1HY1 antibody
    • IL-1L1 antibody
    • IL-1ra homolog 1 antibody
    • IL-1RP3 antibody
    • IL1F5 antibody
    • IL1HY1 antibody
    • IL1L1 antibody
    • IL1RP3 antibody
    • IL36RA antibody
    • IL36RN antibody
    • Interleukin 1 delta antibody
    • Interleukin 1 family member 5 (delta) antibody
    • Interleukin 1 family member 5 antibody
    • Interleukin 1 HY1 antibody
    • Interleukin 1 like protein 1 antibody
    • Interleukin 1 receptor antagonist homolog 1 antibody
    • Interleukin 36 receptor antagonist antibody
    • Interleukin-1 delta antibody
    • Interleukin-1 family member 5 antibody
    • Interleukin-1 HY1 antibody
    • Interleukin-1 receptor antagonist homolog 1 antibody
    • Interleukin-1-like protein 1 antibody
    • Interleukin-36 receptor antagonist protein antibody
    • MGC29840 antibody
    • PSORP antibody
    • RP23-176J12.6 antibody
    see all

References

ab90931 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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