Anti-IL4 antibody [EPR1118Y] (ab62351)

Overview

• Product name
  Anti-IL4 antibody [EPR1118Y]
  See all IL4 primary antibodies
• Description
  Rabbit monoclonal [EPR1118Y] to IL4
• Tested applications
  Suitable for: Flow Cyt, WB, ICC/IFmore details
  Unsuitable for: IHC-P or IP
• Species reactivity
  Reacts with: Human
  
• Immunogen

  A synthetic peptide corresponding to residues in human IL4

• Positive control
  • Human tonsil lysate
• General notes

  Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

  Produced using Abcam's RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5, 675, 063 and/or 7, 429, 487.

  This product is a recombinant rabbit monoclonal antibody.

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage buffer
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Purity
  Tissue culture supernatant
• Clonality
  Monoclonal
• Clone number
  EPR1118Y
• Isotype
  IgG
• Research areas
  • Immunology
  • Innate Immunity
  • Cytokines
  • Interleukins

  • Cancer
  • Tumor immunology
  • Cytokines
  • Interleukins

  • Immunology
  • Adaptive Immunity
  • Regulatory T Cells

Associated products

• Alternative Versions
  • Anti-IL4 antibody [EPR1118Y] (Alexa Fluor® 568) (ab211212)
  • Anti-IL4 antibody [EPR1118Y] (Alexa Fluor® 488) (ab211374)

Applications

Target

• Function
  Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
• Involvement in disease
  Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
• Sequence similarities
  Belongs to the IL-4/IL-13 family.
• Cellular localization
  Secreted.

• Target information above from: UniProt accession P05112 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 3565 Human
  • Omim: 147780 Human
  • SwissProt: P05112 Human
  • Unigene: 73917 Human
• Alternative names
  • B cell growth factor 1 antibody
  • B cell IgG differentiation factor antibody
  • B Cell Stimulatory Factor 1 antibody

  • B-cell stimulatory factor 1 antibody
  • BCGF 1 antibody
  • BCGF1 antibody
  • Binetrakin antibody
  • BSF-1 antibody
  • BSF1 antibody
  • IGG1 induction factor antibody
  • IL 4 antibody
  • IL-4 antibody
  • IL4 antibody
  • IL4_HUMAN antibody
  • Il4e12 antibody
  • Interleukin 4 antibody
  • Interleukin 4 variant 2 antibody
  • Interleukin 4, isoform 1 antibody
  • Interleukin-4 antibody
  • Lymphocyte stimulatory factor 1 antibody
  • MGC79402 antibody
  • Pitrakinra antibody

  see all

Protocols

• Flow cytometry protocols
• Immunocytochemistry & immunofluorescence protocols
• Western blot protocols