• Product nameAnti-IL6 antibody [5E1]
    See all IL6 primary antibodies
  • Description
    Mouse monoclonal [5E1] to IL6
  • SpecificityThe antibody reacts with human native and recombinant IL-6 (assessed by ELISA)
  • Tested applicationsSuitable for: ELISA, IHC-Fr, Inhibition Assay, WBmore details
  • Species reactivity
    Reacts with: Cynomolgus Monkey, Rhesus monkey



Our Abpromise guarantee covers the use of ab8472 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Inhibition Assay
  • Application notesThis antibody inhibits of the biological activity of human native and recombinant IL-6 (determined with the B9 cell bioassay).
    1 ml of the antibody solution inhibits approximately 0.33µg of IL-6 per ml.
    Before use in biological assays, this antibody must be filter-sterilized and depending on the concentration to be used dialyzed against culture medium to remove sodium azide.
    Dilutions have to be made according to the amount of IL-6 to be inactivated.
    For Western blots the material should not be diluted.
  • Target

    • FunctionCytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
    • Involvement in diseaseGenetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
      Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
    • Sequence similaritiesBelongs to the IL-6 superfamily.
    • Post-translational
      N- and O-glycosylated.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Alternative names
      • Interleukin BSF 2 antibody
      • B cell differentiation factor antibody
      • B cell stimulatory factor 2 antibody
      • B-cell stimulatory factor 2 antibody
      • BSF 2 antibody
      • BSF-2 antibody
      • BSF2 antibody
      • CDF antibody
      • CTL differentiation factor antibody
      • Hepatocyte stimulatory factor antibody
      • HGF antibody
      • HSF antibody
      • Hybridoma growth factor antibody
      • Hybridoma growth factor Interferon beta-2 antibody
      • IFN-beta-2 antibody
      • IFNB2 antibody
      • IL 6 antibody
      • IL-6 antibody
      • IL6 antibody
      • IL6_HUMAN antibody
      • Interferon beta 2 antibody
      • Interferon beta-2 antibody
      • Interleukin 6 antibody
      • Interleukin 6 (interferon beta 2) antibody
      • Interleukin BSF 2 antibody
      • Interleukin-6 antibody
      see all

    References for Anti-IL6 antibody [5E1] (ab8472)

    ab8472 has not yet been referenced specifically in any publications.

    Product Wall

    No, as yet, this antibody has only been tested on frozen sections