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ab6672 has been referenced in 109 publications.

  • Liu Z  et al. Mark4 promotes oxidative stress and inflammation via binding to PPAR? and activating NF-?B pathway in mice adipocytes. Sci Rep 6:21382 (2016). WB ; Mouse . PubMed: 26888669
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  • Garcia PV  et al. Increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of P-MAPA biological response modifier. BMC Cancer 16:422 (2016). WB, IHC . PubMed: 27389279
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  • Tarry-Adkins JL  et al. Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats. Dis Model Mech 9:1221-1229 (2016). PubMed: 27585884
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  • Shi KL  et al. Atorvastatin antagonizes the visfatin-induced expression of inflammatory mediators via the upregulation of NF-?B activation in HCAECs. Oncol Lett 12:1438-1444 (2016). Human . PubMed: 27446449
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  • Kanazawa K  et al. Preventing effects of joint contracture by high molecular weight hyaluronan injections in a rat immobilized knee model. Int J Clin Exp Pathol 8:3426-40 (2015). IHC-P ; Rat . PubMed: 26097527
  • Ma X  et al. Modulation of tumorigenesis by the pro-inflammatory microRNA miR-301a in mouse models of lung cancer and colorectal cancer. Cell Discov 1:15005 (2015). IHC-P ; Mouse . PubMed: 27462406
  • Arosh JA  et al. Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis. Proc Natl Acad Sci U S A 112:9716-21 (2015). IHC-Fr ; Mouse . PubMed: 26199416
  • Nyström A  et al. Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms. EMBO Mol Med 7:1211-28 (2015). WB ; Human . PubMed: 26194911
  • Gargus M  et al. Human esophageal myofibroblasts secrete proinflammatory cytokines in response to acid and Toll-like receptor 4 ligands. Am J Physiol Gastrointest Liver Physiol 308:G904-23 (2015). IHC-P ; Human . PubMed: 25882613
  • Lanzini M  et al. In Vivo and Impression Cytology Study on the Effect of Compatible Solutes Eye Drops on the Ocular Surface Epithelial Cell Quality in Dry Eye Patients. Mediators Inflamm 2015:351424 (2015). PubMed: 26221061
  • Mastropasqua R  et al. Corneoscleral limbus in glaucoma patients: in vivo confocal microscopy and immunocytological study. Invest Ophthalmol Vis Sci 56:2050-8 (2015). PubMed: 25744981
  • Kim C  et al. Hypoestoxide reduces neuroinflammation and a-synuclein accumulation in a mouse model of Parkinson's disease. J Neuroinflammation 12:236 (2015). IF, IHC ; Mouse . PubMed: 26683203
  • da Rocha AL  et al. Downhill Running-Based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway without Concomitant Decrease of Inflammatory Proteins. PLoS One 10:e0140020 (2015). PubMed: 26445495
  • Moghimi E  et al. Dietary Vitamin D3 Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral Sclerosis. PLoS One 10:e0126355 (2015). WB ; Mouse . PubMed: 26020962
  • Marino FE  et al. Activin-ßC modulates cachexia by repressing the ubiquitin-proteasome and autophagic degradation pathways. J Cachexia Sarcopenia Muscle 6:365-80 (2015). WB ; Mouse . PubMed: 26673867
  • Majumder B  et al. Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity. Nat Commun 6:6169 (2015). IHC-P ; Human . PubMed: 25721094
  • Yang S  et al. Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity. Redox Biol 3:63-71 (2014). WB ; Rat . PubMed: 25462067
  • Van Hung T  et al. Inhibition of vascular endothelial growth factor receptor under hypoxia causes severe, human-like pulmonary arterial hypertension in mice: potential roles of interleukin-6 and endothelin. Life Sci 118:313-28 (2014). Mouse . PubMed: 24412382
  • Zhang J  et al. Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor ?B. Neuroscience 261:1-10 (2014). Rat . PubMed: 24365462
  • Ansar S  et al. Pro-inflammatory mediators and apoptosis correlate to rt-PA response in a novel mouse model of thromboembolic stroke. PLoS One 9:e85849 (2014). ICC/IF ; Mouse . PubMed: 24465746
  • Marongiu F  et al. Clearance of senescent hepatocytes in a neoplastic-prone microenvironment delays the emergence of hepatocellular carcinoma. Aging (Albany NY) 6:26-34 (2014). WB ; Rat . PubMed: 24464501
  • Ju X  et al. IL-6 regulates extracellular matrix remodeling associated with aortic dilation in a fibrillin-1 hypomorphic mgR/mgR mouse model of severe Marfan syndrome. J Am Heart Assoc 3:e000476 (2014). IHC-P ; Mouse . PubMed: 24449804
  • Samraj AK  et al. Role of unphosphorylated transcription factor STAT3 in late cerebral ischemia after subarachnoid hemorrhage. J Cereb Blood Flow Metab 34:759-63 (2014). PubMed: 24517975
  • Zhen J  et al. AIM2 mediates inflammation-associated renal damage in hepatitis B virus-associated glomerulonephritis by regulating caspase-1, IL-1ß, and IL-18. Mediators Inflamm 2014:190860 (2014). WB ; Human . PubMed: 24701032
  • Qian H  et al. Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats. World J Gastroenterol 20:1822-32 (2014). IHC ; Rat . PubMed: 24587659
  • Huang Y  et al. Perineural dexmedetomidine attenuates inflammation in rat sciatic nerve via the NF-?B pathway. Int J Mol Sci 15:4049-59 (2014). WB ; Rat . PubMed: 24663080
  • Codeluppi S  et al. Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signaling. PLoS One 9:e92649 (2014). IHC (PFA fixed) ; Rat . PubMed: 24667246
  • Norris CA  et al. Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli. PLoS One 9:e96053 (2014). WB, ICC/IF ; Mouse, Rat . PubMed: 24763697
  • Hanin G  et al. Competing targets of microRNA-608 affect anxiety and hypertension. Hum Mol Genet N/A:N/A (2014). WB . PubMed: 24722204
  • Zhang J  et al. RMP promotes venous metastases of hepatocellular carcinoma through promoting IL-6 transcription. Oncogene 0:N/A (2014). PubMed: 24704835
  • Yang B  et al. Comparison of neurodegeneration and cognitive impairment in neonatal mice exposed to propofol or isoflurane. PLoS One 9:e99171 (2014). WB ; Mouse . PubMed: 24932894
  • Qi Y  et al. Autophagy inhibition by sustained overproduction of IL6 contributes to arsenic carcinogenesis. Cancer Res 74:3740-52 (2014). PubMed: 24830721
  • Chow A  et al. Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-?B. Sci Rep 4:5750 (2014). IHC-P, ICC/IF . PubMed: 25034888
  • Llorens F  et al. Subtype and regional-specific neuroinflammation in sporadic creutzfeldt-jakob disease. Front Aging Neurosci 6:198 (2014). WB, IHC-P ; Human . PubMed: 25136317
  • Srodulski S  et al. Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin. Mol Neurodegener 9:30 (2014). WB ; Rat . PubMed: 25149184
  • Sakamoto S  et al. Impact of age-dependent adventitia inflammation on structural alteration of abdominal aorta in hyperlipidemic mice. PLoS One 9:e105739 (2014). IHC-P ; Mouse . PubMed: 25153991
  • Abbondanzo SJ & Chang SL HIV-1 transgenic rats display alterations in immunophenotype and cellular responses associated with aging. PLoS One 9:e105256 (2014). WB ; Rat . PubMed: 25127062
  • Tripathi P  et al. Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms. Oncogene 33:1840-9 (2014). WB, IHC-Fr ; Mouse . PubMed: 23624921
  • Qi Y  et al. PPARa-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate. Am J Physiol Gastrointest Liver Physiol 307:G564-73 (2014). PubMed: 25035112
  • Zabini D  et al. Comprehensive analysis of inflammatory markers in chronic thromboembolic pulmonary hypertension patients. Eur Respir J 44:951-62 (2014). IHC . PubMed: 25034560
  • Chen ZW  et al. TNF-a-induced cardiomyocyte apoptosis contributes to cardiac dysfunction after coronary microembolization in mini-pigs. J Cell Mol Med 18:1953-63 (2014). PubMed: 25130514
  • Felix K  et al. Objective parameters aid the prediction of fistulas in pancreatic surgery. Exp Ther Med 8:719-726 (2014). IHC-Fr ; Human . PubMed: 25120588
  • O'Bryant SE  et al. Validation of a serum screen for Alzheimer's disease across assay platforms, species, and tissues. J Alzheimers Dis 42:1325-35 (2014). IHC-P ; Mouse, Human . PubMed: 25024345
  • Desallais L  et al. Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis. Arthritis Res Ther 16:R157 (2014). IHC . PubMed: 25059342
  • McElwee JL  et al. PAD2 overexpression in transgenic mice promotes spontaneous skin neoplasia. Cancer Res 74:6306-17 (2014). PubMed: 25213324
  • Hao Y  et al. Mycoplasma pneumoniae modulates STAT3-STAT6/EGFR-FOXA2 signaling to induce overexpression of airway mucins. Infect Immun 82:5246-55 (2014). PubMed: 25287927
  • McCarthy RC & Kosman DJ Activation of C6 glioblastoma cell ceruloplasmin expression by neighboring human brain endothelia-derived interleukins in an in vitro blood-brain barrier model system. Cell Commun Signal 12:65 (2014). WB . PubMed: 25311416
  • Ansar S  et al. Characterization of a new model of thromboembolic stroke in C57 black/6J mice. Transl Stroke Res 5:526-33 (2014). IHC-Fr ; Mouse . PubMed: 24347404
  • Yang JM  et al. Angiotensin-(1-7) dose-dependently inhibits atherosclerotic lesion formation and enhances plaque stability by targeting vascular cells. Arterioscler Thromb Vasc Biol 33:1978-85 (2013). IHC (PFA fixed), WB ; Mouse . PubMed: 23723368
  • Padrão AI  et al. Bladder cancer-induced skeletal muscle wasting: disclosing the role of mitochondria plasticity. Int J Biochem Cell Biol 45:1399-409 (2013). PubMed: 23608519
  • Arantes-Rodrigues R  et al. Meloxicam in the treatment of in vitro and in vivo models of urinary bladder cancer. Biomed Pharmacother 67:277-84 (2013). WB ; Mouse . PubMed: 23582791
  • Wagner M  et al. Loss of adipocyte specification and necrosis augment tumor-associated inflammation. Adipocyte 2:176-83 (2013). IHC-P ; Mouse . PubMed: 23991365
  • Qu Y  et al. Generation of prostate tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6/STAT3 signaling. Cancer Res 73:7090-100 (2013). Neutralising ; Human . PubMed: 24101153
  • Ziraldo C  et al. Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies. PLoS One 8:e79804 (2013). ICC/IF ; Mouse . PubMed: 24312451
  • Tavecchio M  et al. Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility. J Biol Chem 288:5553-61 (2013). Neutralising . PubMed: 23303179
  • Tripathy D  et al. Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia. Front Aging Neurosci 5:19 (2013). IHC-P ; Mouse . PubMed: 23675346
  • Zhang L  et al. Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells. Br J Anaesth 110 Suppl 1:i82-91 (2013). PubMed: 23604542
  • Luo C  et al. Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Res 73:4337-48 (2013). PubMed: 23650282
  • Chang Q  et al. The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis. Neoplasia 15:848-62 (2013). IHC-P . PubMed: 23814496
  • Erb HH  et al. IL6 sensitizes prostate cancer to the antiproliferative effect of IFNa2 through IRF9. Endocr Relat Cancer 20:677-89 (2013). PubMed: 23913484
  • Chew SH  et al. Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production. Carcinogenesis N/A:N/A (2013). PubMed: 23917077
  • Piltonen TT  et al. Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential. J Clin Endocrinol Metab 98:3765-75 (2013). PubMed: 23824412
  • Lauritzen HP  et al. Contraction and AICAR stimulate IL-6 vesicle depletion from skeletal muscle fibers in vivo. Diabetes 62:3081-92 (2013). PubMed: 23761105
  • Mao P  et al. MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. Biochim Biophys Acta 1832:2322-31 (2013). PubMed: 24055980
  • Eckle T  et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol 11:e1001665 (2013). PubMed: 24086109
  • Li S  et al. Cathepsin B Contributes to Autophagy-related 7 (Atg7)-induced Nod-like Receptor 3 (NLRP3)-dependent Proinflammatory Response and Aggravates Lipotoxicity in Rat Insulinoma Cell Line. J Biol Chem 288:30094-104 (2013). WB ; Rat . PubMed: 23986436
  • Gu H  et al. Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis. Cell Death Dis 4:e816 (2013). Rat . PubMed: 24091659
  • Horstmann L  et al. Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model. J Neuroinflammation 10:120 (2013). IHC-P ; Mouse . PubMed: 24090415
  • Wagner M  et al. Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. Angiogenesis 15:481-95 (2012). IHC ; Mouse . PubMed: 22614697
  • Rivas DA  et al. Increased ceramide content and NF?B signaling may contribute to the attenuation of anabolic signaling after resistance exercise in aged males. J Appl Physiol 113:1727-36 (2012). PubMed: 23042913
  • Giwa MO  et al. Neuropathologic evidence of endothelial changes in cerebral small vessel disease. Neurology 78:167-74 (2012). PubMed: 22170884
  • Li Y  et al. IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer. Carcinogenesis 33:1889-96 (2012). IHC-P ; Human . PubMed: 22739025
  • Wu X  et al. The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-a, IL-6, and IL-1ß. Neurobiol Aging 33:1364-78 (2012). WB ; Mouse . PubMed: 21190757
  • Yan S  et al. Pretreatment of cisplatin in recipients attenuates post-transplantation pancreatitis in murine model. Int J Biol Sci 8:298-309 (2012). PubMed: 22355266
  • Alcazar MA  et al. Early postnatal hyperalimentation impairs renal function via SOCS-3 mediated renal postreceptor leptin resistance. Endocrinology 153:1397-410 (2012). WB ; Rat . PubMed: 22253420
  • Luikart BW  et al. miR-132 mediates the integration of newborn neurons into the adult dentate gyrus. PLoS One 6:e19077 (2011). IHC-FrFl ; Mouse . PubMed: 21611182
  • Lau K  et al. Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias. J Immunol 186:3538-46 (2011). Neutralising ; Mouse . PubMed: 21317395
  • Price LC  et al. Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats. Eur Respir J 37:813-22 (2011). IHC-Fr ; Rat . PubMed: 20693255
  • Elsawa SF  et al. Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity. Blood 118:5540-9 (2011). IHC-P ; Human . PubMed: 21921047
  • Li Y  et al. Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. Gut 59:227-35 (2010). IHC-P ; Human . PubMed: 19926618
  • Maddahi A & Edvinsson L Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway. J Neuroinflammation 7:14 (2010). IHC-Fr ; Rat . PubMed: 20187933
  • García-Lastra R  et al. Signaling pathways involved in liver injury and regeneration in rabbit hemorrhagic disease, an animal model of virally-induced fulminant hepatic failure. Vet Res 41:2 (2010). WB ; Mouse . PubMed: 19726019
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  • Weiser-Evans MC  et al. Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis. Cancer Res 69:1733-8 (2009). IHC-P ; Mouse . PubMed: 19208832
  • Baban B  et al. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J Immunol 183:2475-83 (2009). IHC-P ; Mouse . PubMed: 19635913
  • Katsifis GE  et al. Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis. Am J Pathol 175:1167-77 (2009). IHC-P ; Human . PubMed: 19700754
  • Kim JY  et al. Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis. Biochim Biophys Acta 1793:1759-67 (2009). WB, Neutralising ; Human, Rat . PubMed: 19751774
  • Pflegerl P  et al. Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling. Proc Natl Acad Sci U S A 106:20423-8 (2009). IHC-P ; Mouse . PubMed: 19918056
  • Manczak M  et al. Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease. Hum Mol Genet 18:3876-93 (2009). IHC-Fr ; Mouse . PubMed: 19617638
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  • Hnia K  et al. L-arginine decreases inflammation and modulates the nuclear factor-kappaB/matrix metalloproteinase cascade in mdx muscle fibers. Am J Pathol 172:1509-19 (2008). WB, IHC-Fr ; Mouse . PubMed: 18458097
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  • Jiménez-Jiménez R  et al. Eccentric training impairs NF-kappaB activation and over-expression of inflammation-related genes induced by acute eccentric exercise in the elderly. Mech Ageing Dev 129:313-21 (2008). PubMed: 18377953
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