Biological descriptionHighly potent H3 and H4 receptor agonist (Ki values are 0.3 and 2.7 nM, respectively). Centrally active following systemic administration. Displays various biological activities.
Chemical nameS-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Kathmann M et al. Nordimaprit, homodimaprit, clobenpropit and imetit: affinities for H3 binding sites and potencies in a functional H3 receptor model. Naunyn Schmiedebergs Arch Pharmacol348:498-503 (1993).
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Garbarg M et al. S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J Pharmacol Exp Ther263:304-10 (1992).
Read more (PubMed: 1383495) »